| Name | PA | R | RBI | BA | OBP | SLG | POS |
|---|---|---|---|---|---|---|---|
| David Ortiz | 667 | 116 | 117 | 0.332 | 0.445 | 0.621 | DH |
| Mike Lowell | 653 | 79 | 120 | 0.324 | 0.378 | 0.501 | 3B |
| Julio Lugo | 630 | 71 | 73 | 0.237 | 0.294 | 0.349 | SS |
| Kevin Youkilis | 625 | 85 | 83 | 0.288 | 0.390 | 0.453 | 1B-3B |
| Coco Crisp | 591 | 85 | 60 | 0.268 | 0.330 | 0.382 | CF |
| Dustin Pedroia | 581 | 86 | 50 | 0.317 | 0.380 | 0.442 | 2B |
| Manny Ramirez | 569 | 84 | 88 | 0.296 | 0.388 | 0.493 | LF-DH |
| J.D. Drew | 552 | 84 | 64 | 0.270 | 0.373 | 0.423 | RF |
| Jason Varitek | 518 | 57 | 68 | 0.255 | 0.367 | 0.421 | CR |
| Alex Cora | 232 | 30 | 18 | 0.246 | 0.298 | 0.386 | 2B-SS |
| Eric Hinske | 218 | 25 | 21 | 0.204 | 0.317 | 0.398 | 1B-LF-RF |
| Wily Mo Pena | 172 | 18 | 17 | 0.218 | 0.291 | 0.385 | RF-LF-CF |
| Jacoby Ellsbury | 127 | 20 | 18 | 0.353 | 0.394 | 0.509 | LF-CF |
| Doug Mirabelli | 127 | 9 | 16 | 0.202 | 0.278 | 0.360 | CR |
| Bobby Kielty | 61 | 6 | 9 | 0.231 | 0.295 | 0.327 | LF-RF |
| Kevin Cash | 33 | 2 | 4 | 0.111 | 0.242 | 0.148 | CR |
| Brandon Moss | 29 | 6 | 1 | 0.280 | 0.379 | 0.440 | LF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | 0.444 | |
| Royce Clayton | 6 | 1 | 0 | 0.000 | 0.000 | 0.000 | |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 1.500 |
| Name | IP | ERA | Gs | Gr | SO | WHIP |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 204.3 | 4.40 | 32 | 0 | 201 | 1.32 |
| Josh Beckett | 200.3 | 3.27 | 30 | 0 | 194 | 1.14 |
| Tim Wakefield | 189.0 | 4.76 | 31 | 0 | 110 | 1.35 |
| Curt Schilling | 151.0 | 3.87 | 24 | 0 | 101 | 1.25 |
| Julian Tavarez | 134.3 | 5.15 | 23 | 11 | 77 | 1.50 |
| Hideki Okajima | 69.0 | 2.22 | 0 | 66 | 63 | 0.97 |
| Jon Lester | 63.0 | 4.57 | 11 | 1 | 50 | 1.46 |
| Jonathan Papelbon | 58.0 | 1.85 | 0 | 59 | 84 | 0.77 |
| Mike Timlin | 55.0 | 3.42 | 0 | 50 | 31 | 1.08 |
| Kyle Snyder | 54.0 | 3.81 | 0 | 46 | 41 | 1.42 |
| Manny Delcarmen | 44.0 | 2.05 | 0 | 44 | 41 | 1.02 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | 29 | 1.12 |
| Javier Lopez | 40.3 | 3.10 | 0 | 61 | 26 | 1.33 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | 20 | 1.62 |
| Clay Buchholz | 22.3 | 1.59 | 3 | 1 | 22 | 1.06 |
| Brendan Donnelly | 20.3 | 3.05 | 0 | 27 | 15 | 1.16 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | 11 | 1.95 |
| Eric Gagne | 18.3 | 6.75 | 0 | 20 | 22 | 1.88 |
| Bryan Corey | 9.0 | 1.93 | 0 | 9 | 6 | 1.07 |
| Devern Hansack | 7.3 | 4.70 | 1 | 2 | 5 | 1.83 |
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