| Name | PA | R | RBI | BA | OBP | SLG | POS |
|---|---|---|---|---|---|---|---|
| Grady Sizemore | 748 | 118 | 78 | 0.277 | 0.390 | 0.462 | CF |
| Casey Blake | 662 | 81 | 78 | 0.270 | 0.339 | 0.437 | 3B-1B |
| Travis Hafner | 661 | 80 | 100 | 0.266 | 0.385 | 0.451 | DH-1B |
| Jhonny Peralta | 647 | 87 | 72 | 0.270 | 0.341 | 0.430 | SS |
| Victor Martinez | 645 | 78 | 114 | 0.301 | 0.374 | 0.505 | CR-1B |
| Ryan Garko | 541 | 62 | 61 | 0.289 | 0.359 | 0.483 | 1B |
| Josh Barfield | 444 | 53 | 50 | 0.243 | 0.270 | 0.324 | 2B |
| Trot Nixon | 354 | 30 | 31 | 0.251 | 0.342 | 0.336 | RF |
| Franklin Gutierrez | 301 | 41 | 36 | 0.266 | 0.318 | 0.472 | RF |
| Jason Michaels | 295 | 43 | 39 | 0.270 | 0.324 | 0.397 | LF-RF |
| David Dellucci | 199 | 25 | 20 | 0.230 | 0.296 | 0.382 | LF |
| Kenny Lofton | 196 | 24 | 15 | 0.283 | 0.344 | 0.370 | LF |
| Asdrubal Cabrera | 186 | 30 | 22 | 0.283 | 0.354 | 0.421 | 2B |
| Kelly Shoppach | 177 | 26 | 30 | 0.261 | 0.310 | 0.472 | CR |
| Mike Rouse | 76 | 7 | 4 | 0.119 | 0.200 | 0.134 | 2B-3B-SS |
| Ben Francisco | 66 | 10 | 12 | 0.274 | 0.303 | 0.500 | LF |
| Andy Marte | 60 | 3 | 8 | 0.193 | 0.233 | 0.316 | 3B |
| Chris Gomez | 55 | 4 | 5 | 0.283 | 0.278 | 0.321 | |
| Shin-Soo Choo | 20 | 5 | 5 | 0.294 | 0.350 | 0.294 | |
| Luis Rivas | 11 | 3 | 4 | 0.273 | 0.273 | 0.727 |
| Name | IP | ERA | Gs | Gr | SO | WHIP |
|---|---|---|---|---|---|---|
| CC Sabathia | 241.0 | 3.21 | 34 | 0 | 209 | 1.14 |
| Roberto Hernandez | 215.0 | 3.06 | 32 | 0 | 137 | 1.21 |
| Paul Byrd | 192.0 | 4.59 | 31 | 0 | 88 | 1.39 |
| Jake Westbrook | 152.0 | 4.32 | 25 | 0 | 93 | 1.41 |
| Cliff Lee | 97.0 | 6.29 | 16 | 4 | 66 | 1.52 |
| Rafael Betancourt | 79.0 | 1.47 | 0 | 68 | 80 | 0.76 |
| Jeremy Sowers | 67.0 | 6.42 | 13 | 0 | 24 | 1.56 |
| Joe Borowski | 65.3 | 5.07 | 0 | 69 | 58 | 1.43 |
| Rafael Perez | 60.3 | 1.78 | 0 | 44 | 62 | 0.92 |
| Tom Mastny | 57.3 | 4.68 | 0 | 51 | 52 | 1.65 |
| Aaron Laffey | 49.0 | 4.56 | 9 | 0 | 25 | 1.34 |
| Aaron Fultz | 37.0 | 2.92 | 0 | 49 | 28 | 1.32 |
| Fernando Cabrera | 33.3 | 5.61 | 0 | 24 | 39 | 1.78 |
| Jensen Lewis | 29.0 | 2.15 | 0 | 26 | 34 | 1.23 |
| Jason Stanford | 26.0 | 4.78 | 2 | 6 | 16 | 1.48 |
| Roberto Hernandez | 26.0 | 6.23 | 0 | 28 | 18 | 1.89 |
| Edward Mujica | 13.0 | 8.31 | 0 | 10 | 7 | 1.61 |
| Jason Davis | 11.0 | 4.76 | 0 | 8 | 5 | 1.94 |
| Mike Koplove | 6.0 | 6.00 | 0 | 5 | 4 | 1.33 |
| Juan Lara | 1.0 | 13.50 | 0 | 1 | 2 | 2.25 |
| Matt Miller | 1.0 | 0.00 | 0 | 2 | 0 | 2.00 |
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