| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Manny Ramirez | 368 | 49 | 50 | 0.288 | 0.386 | 1.42 | LF-DH |
| David Ortiz | 367 | 58 | 54 | 0.318 | 0.436 | 2.81 | DH |
| Kevin Youkilis | 352 | 51 | 45 | 0.324 | 0.418 | 1.50 | 1B-3B |
| Julio Lugo | 347 | 35 | 39 | 0.201 | 0.268 | -0.69 | SS |
| Mike Lowell | 344 | 39 | 66 | 0.302 | 0.352 | 2.64 | 3B |
| Coco Crisp | 328 | 43 | 28 | 0.261 | 0.311 | -0.54 | CF |
| J.D. Drew | 311 | 51 | 34 | 0.260 | 0.370 | 1.34 | RF |
| Dustin Pedroia | 288 | 38 | 25 | 0.312 | 0.392 | -0.41 | 2B |
| Jason Varitek | 287 | 33 | 36 | 0.278 | 0.366 | 0.25 | CR |
| Alex Cora | 143 | 15 | 15 | 0.278 | 0.315 | -0.34 | 2B-SS |
| Wily Mo Pena | 134 | 13 | 12 | 0.213 | 0.284 | -0.64 | LF |
| Eric Hinske | 105 | 13 | 11 | 0.191 | 0.305 | -0.04 | 1B-LF-RF |
| Doug Mirabelli | 85 | 3 | 9 | 0.182 | 0.259 | -0.81 | CR |
| Jacoby Ellsbury | 18 | 3 | 1 | 0.375 | 0.444 | -0.02 | LF-CF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 119.7 | 3.84 | 18 | 0 | X | 1.49 |
| Tim Wakefield | 112.7 | 4.47 | 18 | 0 | X | -0.27 |
| Josh Beckett | 102.0 | 3.44 | 16 | 0 | X | 2.21 |
| Curt Schilling | 94.3 | 4.20 | 15 | 0 | X | 0.38 |
| Julian Tavarez | 92.7 | 5.15 | 17 | 0 | X | -1.68 |
| Hideki Okajima | 44.3 | 0.81 | 0 | 40 | X | 3.68 |
| Kyle Snyder | 33.7 | 3.21 | 0 | 29 | X | 0.91 |
| Jonathan Papelbon | 33.7 | 1.87 | 0 | 33 | X | 1.96 |
| Joel Pineiro | 31.0 | 4.94 | 0 | 28 | X | -0.41 |
| Mike Timlin | 27.0 | 4.00 | 0 | 23 | X | 0.23 |
| Javier Lopez | 24.3 | 2.96 | 0 | 35 | X | 0.80 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.64 |
| Kason Gabbard | 20.3 | 4.87 | 4 | 0 | X | -0.24 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.57 |
| Manny Delcarmen | 11.7 | 1.54 | 0 | 11 | X | 0.77 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
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