| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Manny Ramirez | 407 | 57 | 57 | 0.295 | 0.396 | 2.03 | LF-DH |
| David Ortiz | 397 | 61 | 60 | 0.321 | 0.433 | 3.00 | DH |
| Kevin Youkilis | 386 | 56 | 47 | 0.310 | 0.407 | 1.38 | 1B-3B |
| Julio Lugo | 384 | 42 | 46 | 0.224 | 0.286 | -0.14 | SS |
| Mike Lowell | 380 | 46 | 70 | 0.306 | 0.358 | 2.90 | 3B |
| Coco Crisp | 366 | 49 | 38 | 0.277 | 0.328 | 0.19 | CF |
| J.D. Drew | 339 | 55 | 38 | 0.253 | 0.363 | 1.48 | RF |
| Dustin Pedroia | 323 | 41 | 29 | 0.320 | 0.393 | -0.54 | 2B |
| Jason Varitek | 310 | 37 | 41 | 0.269 | 0.355 | 0.62 | CR |
| Alex Cora | 152 | 17 | 15 | 0.267 | 0.303 | -0.35 | 2B-SS |
| Wily Mo Pena | 142 | 13 | 12 | 0.202 | 0.275 | -0.84 | LF |
| Eric Hinske | 122 | 16 | 14 | 0.217 | 0.311 | 0.17 | 1B-LF-RF |
| Doug Mirabelli | 97 | 4 | 10 | 0.182 | 0.258 | -0.90 | CR |
| Jacoby Ellsbury | 18 | 3 | 1 | 0.375 | 0.444 | -0.02 | LF-CF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 130.7 | 3.99 | 20 | 0 | X | 1.13 |
| Tim Wakefield | 125.3 | 4.74 | 20 | 0 | X | -1.09 |
| Josh Beckett | 116.0 | 3.41 | 18 | 0 | X | 2.58 |
| Julian Tavarez | 97.3 | 5.27 | 18 | 0 | X | -2.06 |
| Curt Schilling | 94.3 | 4.20 | 15 | 0 | X | 0.37 |
| Hideki Okajima | 48.7 | 0.92 | 0 | 44 | X | 3.91 |
| Kason Gabbard | 36.3 | 2.97 | 6 | 0 | X | 1.18 |
| Jonathan Papelbon | 35.7 | 1.77 | 0 | 35 | X | 2.16 |
| Kyle Snyder | 35.7 | 3.03 | 0 | 31 | X | 1.11 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.53 |
| Mike Timlin | 31.3 | 3.45 | 0 | 26 | X | 0.67 |
| Javier Lopez | 27.0 | 3.33 | 0 | 38 | X | 0.65 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.64 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.57 |
| Manny Delcarmen | 16.0 | 1.69 | 0 | 15 | X | 1.00 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
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