| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Manny Ramirez | 424 | 62 | 63 | 0.303 | 0.403 | 2.73 | LF-DH |
| David Ortiz | 406 | 63 | 60 | 0.320 | 0.433 | 2.97 | DH |
| Kevin Youkilis | 403 | 60 | 48 | 0.308 | 0.404 | 1.46 | 1B-3B |
| Julio Lugo | 398 | 42 | 46 | 0.224 | 0.284 | -0.51 | SS |
| Mike Lowell | 394 | 46 | 73 | 0.308 | 0.358 | 2.84 | 3B |
| Coco Crisp | 384 | 54 | 39 | 0.282 | 0.331 | 0.35 | CF |
| J.D. Drew | 350 | 55 | 39 | 0.247 | 0.354 | 1.29 | RF |
| Dustin Pedroia | 342 | 43 | 30 | 0.315 | 0.386 | -0.72 | 2B |
| Jason Varitek | 325 | 38 | 43 | 0.268 | 0.357 | 0.54 | CR |
| Alex Cora | 155 | 17 | 15 | 0.268 | 0.303 | -0.44 | 2B-SS |
| Wily Mo Pena | 150 | 15 | 16 | 0.219 | 0.287 | -0.42 | LF |
| Eric Hinske | 129 | 16 | 14 | 0.205 | 0.302 | -0.01 | 1B-LF-RF |
| Doug Mirabelli | 97 | 4 | 10 | 0.182 | 0.258 | -0.91 | CR |
| Jacoby Ellsbury | 18 | 3 | 1 | 0.375 | 0.444 | -0.02 | LF-CF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 137.7 | 3.79 | 21 | 0 | X | 1.88 |
| Tim Wakefield | 125.3 | 4.74 | 20 | 0 | X | -1.06 |
| Josh Beckett | 124.0 | 3.27 | 19 | 0 | X | 3.21 |
| Julian Tavarez | 99.7 | 5.15 | 18 | 1 | X | -1.79 |
| Curt Schilling | 94.3 | 4.20 | 15 | 0 | X | 0.39 |
| Hideki Okajima | 50.7 | 0.89 | 0 | 46 | X | 4.12 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.62 |
| Jonathan Papelbon | 36.7 | 1.72 | 0 | 36 | X | 2.27 |
| Kyle Snyder | 35.7 | 3.03 | 0 | 31 | X | 1.12 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.52 |
| Mike Timlin | 32.7 | 3.31 | 0 | 27 | X | 0.82 |
| Javier Lopez | 28.3 | 3.18 | 0 | 40 | X | 0.79 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.64 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.57 |
| Manny Delcarmen | 17.3 | 1.56 | 0 | 16 | X | 1.14 |
| Jon Lester | 6.0 | 3.00 | 1 | 0 | X | 0.19 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
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