| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Manny Ramirez | 448 | 65 | 67 | 0.296 | 0.393 | 2.89 | LF-DH |
| David Ortiz | 431 | 69 | 65 | 0.321 | 0.434 | 3.51 | DH |
| Kevin Youkilis | 427 | 64 | 57 | 0.304 | 0.400 | 2.25 | 1B-3B |
| Julio Lugo | 425 | 46 | 48 | 0.221 | 0.285 | -0.54 | SS |
| Mike Lowell | 416 | 47 | 73 | 0.305 | 0.356 | 2.41 | 3B |
| Coco Crisp | 406 | 57 | 42 | 0.279 | 0.337 | 0.45 | CF |
| J.D. Drew | 362 | 57 | 41 | 0.248 | 0.354 | 1.42 | RF |
| Dustin Pedroia | 356 | 45 | 31 | 0.318 | 0.388 | -0.74 | 2B |
| Jason Varitek | 340 | 40 | 45 | 0.272 | 0.368 | 0.60 | CR |
| Alex Cora | 165 | 19 | 15 | 0.253 | 0.297 | -0.47 | 2B-SS |
| Wily Mo Pena | 159 | 15 | 16 | 0.221 | 0.289 | -0.64 | LF |
| Eric Hinske | 131 | 16 | 14 | 0.204 | 0.305 | -0.06 | 1B-LF-RF |
| Doug Mirabelli | 104 | 4 | 11 | 0.183 | 0.260 | -0.97 | CR |
| Jacoby Ellsbury | 18 | 3 | 1 | 0.375 | 0.444 | -0.02 | LF-CF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 144.0 | 3.69 | 22 | 0 | X | 2.33 |
| Josh Beckett | 132.0 | 3.41 | 20 | 0 | X | 2.99 |
| Tim Wakefield | 131.3 | 4.59 | 21 | 0 | X | -0.65 |
| Julian Tavarez | 106.0 | 5.09 | 19 | 3 | X | -1.77 |
| Curt Schilling | 94.3 | 4.20 | 15 | 0 | X | 0.40 |
| Hideki Okajima | 52.7 | 1.03 | 0 | 48 | X | 4.12 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.62 |
| Kyle Snyder | 40.3 | 2.68 | 0 | 34 | X | 1.60 |
| Jonathan Papelbon | 38.7 | 2.09 | 0 | 38 | X | 2.06 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.52 |
| Mike Timlin | 32.7 | 3.31 | 0 | 27 | X | 0.82 |
| Javier Lopez | 30.3 | 2.97 | 0 | 43 | X | 1.00 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.64 |
| Manny Delcarmen | 20.3 | 3.10 | 0 | 19 | X | 0.61 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.57 |
| Jon Lester | 12.7 | 4.26 | 2 | 0 | X | 0.03 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
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