| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Manny Ramirez | 466 | 67 | 71 | 0.299 | 0.393 | 3.08 | LF-DH |
| David Ortiz | 450 | 75 | 68 | 0.326 | 0.438 | 4.00 | DH |
| Kevin Youkilis | 448 | 66 | 58 | 0.302 | 0.397 | 2.05 | 1B-3B |
| Julio Lugo | 438 | 47 | 48 | 0.226 | 0.288 | -0.75 | SS |
| Mike Lowell | 434 | 47 | 75 | 0.305 | 0.357 | 2.18 | 3B |
| Coco Crisp | 425 | 60 | 43 | 0.280 | 0.339 | 0.41 | CF |
| J.D. Drew | 374 | 58 | 42 | 0.246 | 0.353 | 1.34 | RF |
| Dustin Pedroia | 372 | 47 | 34 | 0.321 | 0.392 | -0.60 | 2B |
| Jason Varitek | 353 | 40 | 48 | 0.269 | 0.365 | 0.60 | CR |
| Alex Cora | 174 | 21 | 16 | 0.255 | 0.299 | -0.38 | 2B-SS |
| Wily Mo Pena | 162 | 16 | 16 | 0.218 | 0.290 | -0.61 | LF |
| Eric Hinske | 135 | 18 | 15 | 0.207 | 0.311 | 0.16 | 1B-LF-RF |
| Doug Mirabelli | 108 | 6 | 13 | 0.208 | 0.287 | -0.65 | CR |
| Jacoby Ellsbury | 18 | 3 | 1 | 0.375 | 0.444 | -0.02 | LF-CF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 151.0 | 3.64 | 23 | 0 | X | 2.67 |
| Josh Beckett | 138.7 | 3.31 | 21 | 0 | X | 3.50 |
| Tim Wakefield | 138.3 | 4.55 | 22 | 0 | X | -0.52 |
| Julian Tavarez | 106.0 | 5.09 | 19 | 3 | X | -1.74 |
| Curt Schilling | 94.3 | 4.20 | 15 | 0 | X | 0.43 |
| Hideki Okajima | 54.0 | 1.00 | 0 | 50 | X | 4.27 |
| Kyle Snyder | 41.3 | 2.83 | 0 | 35 | X | 1.51 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.63 |
| Jonathan Papelbon | 39.7 | 2.04 | 0 | 39 | X | 2.18 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.51 |
| Mike Timlin | 34.0 | 3.71 | 0 | 28 | X | 0.54 |
| Javier Lopez | 31.3 | 2.87 | 0 | 44 | X | 1.11 |
| Manny Delcarmen | 22.0 | 2.86 | 0 | 21 | X | 0.78 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.65 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.58 |
| Jon Lester | 17.7 | 5.09 | 3 | 0 | X | -0.29 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
| Eric Gagne | 2.0 | 9.00 | 0 | 2 | X | -0.22 |
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