| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Manny Ramirez | 531 | 72 | 84 | 0.289 | 0.380 | 3.28 | LF-DH |
| Kevin Youkilis | 519 | 72 | 63 | 0.288 | 0.385 | 1.37 | 1B-3B |
| David Ortiz | 514 | 85 | 80 | 0.321 | 0.434 | 4.65 | DH |
| Julio Lugo | 501 | 52 | 60 | 0.241 | 0.295 | -0.60 | SS |
| Mike Lowell | 500 | 53 | 86 | 0.314 | 0.370 | 2.26 | 3B |
| Coco Crisp | 477 | 68 | 46 | 0.272 | 0.331 | 0.21 | CF |
| Dustin Pedroia | 434 | 61 | 38 | 0.323 | 0.392 | -0.31 | 2B |
| J.D. Drew | 433 | 63 | 46 | 0.264 | 0.363 | 0.77 | RF |
| Jason Varitek | 405 | 47 | 52 | 0.261 | 0.353 | 0.41 | CR |
| Alex Cora | 189 | 23 | 17 | 0.257 | 0.302 | -0.46 | 2B-SS |
| Wily Mo Pena | 172 | 18 | 17 | 0.218 | 0.291 | -0.57 | LF |
| Eric Hinske | 150 | 19 | 15 | 0.198 | 0.320 | -0.13 | 1B-LF-RF |
| Doug Mirabelli | 117 | 9 | 16 | 0.212 | 0.291 | -0.26 | CR |
| Jacoby Ellsbury | 22 | 4 | 1 | 0.316 | 0.409 | -0.02 | LF-CF |
| Bobby Kielty | 10 | 1 | 0 | 0.300 | 0.300 | -0.14 | X |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| Brandon Moss | 8 | 1 | 0 | 0.143 | 0.250 | -0.09 | LF |
| Kevin Cash | 7 | 1 | 0 | 0.000 | 0.143 | -0.07 | CR |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 170.0 | 3.71 | 26 | 0 | X | 2.86 |
| Tim Wakefield | 157.3 | 4.35 | 25 | 0 | X | 0.29 |
| Josh Beckett | 154.3 | 3.15 | 23 | 0 | X | 4.60 |
| Julian Tavarez | 116.7 | 5.01 | 20 | 7 | X | -1.60 |
| Curt Schilling | 112.3 | 4.25 | 18 | 0 | X | 0.47 |
| Hideki Okajima | 60.7 | 1.19 | 0 | 56 | X | 4.59 |
| Kyle Snyder | 45.7 | 3.55 | 0 | 38 | X | 0.94 |
| Jonathan Papelbon | 45.7 | 1.77 | 0 | 45 | X | 2.83 |
| Mike Timlin | 42.0 | 3.00 | 0 | 36 | X | 1.40 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.66 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.48 |
| Jon Lester | 33.3 | 5.67 | 6 | 0 | X | -0.97 |
| Javier Lopez | 31.3 | 2.87 | 0 | 44 | X | 1.14 |
| Manny Delcarmen | 28.0 | 2.89 | 0 | 28 | X | 1.00 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.66 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.60 |
| Eric Gagne | 8.0 | 11.25 | 0 | 9 | X | -1.27 |
| Clay Buchholz | 6.0 | 4.50 | 1 | 0 | X | -0.01 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
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