| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Kevin Youkilis | 553 | 76 | 72 | 0.290 | 0.392 | 1.94 | 1B-3B |
| David Ortiz | 551 | 97 | 90 | 0.319 | 0.430 | 6.08 | DH |
| Manny Ramirez | 548 | 80 | 85 | 0.292 | 0.385 | 3.85 | LF-DH |
| Mike Lowell | 538 | 61 | 94 | 0.326 | 0.379 | 3.04 | 3B |
| Julio Lugo | 531 | 55 | 63 | 0.235 | 0.288 | -0.67 | SS |
| Coco Crisp | 514 | 72 | 48 | 0.268 | 0.329 | -0.04 | CF |
| Dustin Pedroia | 468 | 67 | 42 | 0.321 | 0.389 | -0.07 | 2B |
| J.D. Drew | 455 | 66 | 47 | 0.256 | 0.356 | 0.67 | RF |
| Jason Varitek | 427 | 50 | 57 | 0.262 | 0.363 | 0.73 | CR |
| Alex Cora | 204 | 26 | 17 | 0.254 | 0.299 | -0.50 | 2B-SS |
| Wily Mo Pena | 172 | 18 | 17 | 0.218 | 0.291 | -0.56 | LF |
| Eric Hinske | 168 | 20 | 20 | 0.213 | 0.333 | 0.07 | 1B-LF-RF |
| Doug Mirabelli | 117 | 9 | 16 | 0.212 | 0.291 | -0.25 | CR |
| Bobby Kielty | 30 | 5 | 8 | 0.308 | 0.333 | 0.63 | X |
| Jacoby Ellsbury | 22 | 4 | 1 | 0.316 | 0.409 | -0.02 | LF-CF |
| Kevin Cash | 19 | 2 | 1 | 0.143 | 0.368 | -0.15 | CR |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| Brandon Moss | 8 | 1 | 0 | 0.143 | 0.250 | -0.09 | LF |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 176.3 | 3.83 | 27 | 0 | X | 2.52 |
| Josh Beckett | 166.7 | 3.29 | 25 | 0 | X | 4.46 |
| Tim Wakefield | 164.3 | 4.16 | 26 | 0 | X | 1.06 |
| Julian Tavarez | 126.0 | 5.00 | 22 | 7 | X | -1.65 |
| Curt Schilling | 125.3 | 4.02 | 20 | 0 | X | 1.22 |
| Hideki Okajima | 62.3 | 1.59 | 0 | 58 | X | 4.15 |
| Kyle Snyder | 49.3 | 3.65 | 0 | 42 | X | 0.91 |
| Jonathan Papelbon | 47.3 | 1.71 | 0 | 47 | X | 3.01 |
| Mike Timlin | 46.0 | 3.52 | 0 | 39 | X | 0.99 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.68 |
| Javier Lopez | 34.7 | 2.86 | 0 | 49 | X | 1.28 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.47 |
| Jon Lester | 33.3 | 5.67 | 6 | 0 | X | -0.96 |
| Manny Delcarmen | 32.7 | 2.48 | 0 | 32 | X | 1.49 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.67 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.60 |
| Eric Gagne | 10.0 | 9.00 | 0 | 11 | X | -1.06 |
| Clay Buchholz | 6.0 | 4.50 | 1 | 0 | X | -0.01 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
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