| Name | PA | R | RBI | BA | OBP | SLG | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 726 | 118 | 83 | 0.326 | 0.376 | 0.493 | 2B |
| Kevin Youkilis | 621 | 91 | 115 | 0.312 | 0.390 | 0.569 | 1B-3B |
| Jacoby Ellsbury | 609 | 98 | 47 | 0.280 | 0.336 | 0.394 | CF-LF-RF |
| David Ortiz | 491 | 74 | 89 | 0.264 | 0.369 | 0.507 | DH |
| Jason Varitek | 483 | 37 | 43 | 0.220 | 0.313 | 0.359 | CR |
| Mike Lowell | 468 | 58 | 73 | 0.274 | 0.338 | 0.461 | 3B |
| J.D. Drew | 456 | 79 | 64 | 0.280 | 0.408 | 0.519 | RF |
| Manny Ramirez | 425 | 66 | 68 | 0.299 | 0.398 | 0.529 | LF-DH |
| Coco Crisp | 409 | 55 | 41 | 0.283 | 0.344 | 0.407 | CF |
| Julio Lugo | 307 | 27 | 22 | 0.268 | 0.355 | 0.330 | SS |
| Jed Lowrie | 306 | 34 | 46 | 0.258 | 0.339 | 0.400 | SS-3B |
| Sean Casey | 218 | 14 | 17 | 0.322 | 0.381 | 0.392 | 1B-DH |
| Jason Bay | 211 | 39 | 37 | 0.293 | 0.370 | 0.527 | LF |
| Alex Cora | 179 | 14 | 9 | 0.270 | 0.371 | 0.349 | SS |
| Kevin Cash | 162 | 11 | 15 | 0.225 | 0.309 | 0.338 | CR |
| Mark Kotsay | 91 | 6 | 12 | 0.226 | 0.286 | 0.345 | RF |
| Brandon Moss | 86 | 7 | 11 | 0.295 | 0.337 | 0.462 | RF-LF |
| Jeff Bailey | 59 | 10 | 6 | 0.280 | 0.390 | 0.460 | 1B |
| Chris Carter | 20 | 5 | 3 | 0.333 | 0.400 | 0.333 | |
| Jonathan Van Every | 18 | 0 | 5 | 0.235 | 0.278 | 0.353 | |
| David Ross | 9 | 1 | 0 | 0.125 | 0.125 | 0.125 | |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | 0.000 | |
| Gil Velazquez | 8 | 0 | 1 | 0.125 | 0.125 | 0.125 | |
| George Kottaras | 5 | 1 | 0 | 0.200 | 0.200 | 0.400 |
| Name | IP | ERA | Gs | Gr | SO | WHIP |
|---|---|---|---|---|---|---|
| Jon Lester | 210.0 | 3.21 | 33 | 0 | 152 | 1.27 |
| Tim Wakefield | 181.0 | 4.13 | 30 | 0 | 117 | 1.18 |
| Josh Beckett | 174.0 | 4.03 | 27 | 0 | 172 | 1.19 |
| Daisuke Matsuzaka | 167.3 | 2.90 | 29 | 0 | 154 | 1.32 |
| Justin Masterson | 88.0 | 3.16 | 9 | 27 | 68 | 1.22 |
| Clay Buchholz | 76.0 | 6.75 | 15 | 1 | 72 | 1.76 |
| Manny Delcarmen | 74.0 | 3.27 | 0 | 73 | 72 | 1.12 |
| Jonathan Papelbon | 69.0 | 2.34 | 0 | 67 | 77 | 0.95 |
| Hideki Okajima | 62.0 | 2.61 | 0 | 64 | 60 | 1.16 |
| Javier Lopez | 59.0 | 2.43 | 0 | 70 | 38 | 1.35 |
| Mike Timlin | 49.0 | 5.66 | 0 | 47 | 32 | 1.62 |
| Paul Byrd | 49.0 | 4.78 | 8 | 0 | 26 | 1.39 |
| David Aardsma | 48.3 | 5.55 | 0 | 47 | 49 | 1.73 |
| Bartolo Colon | 39.0 | 3.92 | 7 | 0 | 27 | 1.39 |
| Craig Hansen | 30.3 | 5.58 | 0 | 32 | 25 | 1.70 |
| Chris Smith | 18.0 | 7.85 | 0 | 12 | 13 | 1.36 |
| Julian Tavarez | 12.3 | 6.39 | 0 | 9 | 6 | 2.13 |
| David Pauley | 12.0 | 11.68 | 2 | 4 | 11 | 2.27 |
| Devern Hansack | 6.3 | 4.05 | 0 | 4 | 5 | 1.05 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | 4 | 2.33 |
| Michael Bowden | 5.0 | 3.60 | 1 | 0 | 3 | 1.60 |
| Charlie Zink | 4.0 | 16.62 | 1 | 0 | 1 | 2.77 |
| Kyle Snyder | 1.3 | 21.60 | 0 | 2 | 1 | 2.40 |
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