| Name | PA | R | RBI | BA | OBP | SLG | POS |
|---|---|---|---|---|---|---|---|
| Grady Sizemore | 745 | 101 | 90 | 0.268 | 0.374 | 0.502 | CF |
| Jhonny Peralta | 664 | 104 | 89 | 0.276 | 0.331 | 0.473 | SS |
| Ryan Garko | 563 | 61 | 90 | 0.273 | 0.346 | 0.404 | 1B-DH |
| Ben Francisco | 499 | 65 | 54 | 0.266 | 0.332 | 0.438 | LF-RF-DH |
| Franklin Gutierrez | 440 | 54 | 41 | 0.248 | 0.307 | 0.383 | RF-CF-LF |
| Asdrubal Cabrera | 418 | 48 | 47 | 0.259 | 0.346 | 0.366 | 2B-SS |
| Kelly Shoppach | 403 | 67 | 55 | 0.261 | 0.348 | 0.517 | CR |
| Jamey Carroll | 402 | 60 | 36 | 0.277 | 0.355 | 0.346 | 2B-3B |
| David Dellucci | 375 | 41 | 47 | 0.238 | 0.307 | 0.405 | LF-DH |
| Shin-Soo Choo | 370 | 68 | 66 | 0.309 | 0.397 | 0.549 | RF-LF-DH |
| Casey Blake | 368 | 46 | 58 | 0.289 | 0.365 | 0.465 | 3B-1B |
| Victor Martinez | 294 | 30 | 35 | 0.278 | 0.337 | 0.365 | CR-1B |
| Andy Marte | 257 | 21 | 17 | 0.221 | 0.268 | 0.315 | 3B |
| Travis Hafner | 234 | 21 | 24 | 0.197 | 0.305 | 0.323 | DH |
| Jason Michaels | 67 | 3 | 9 | 0.207 | 0.258 | 0.276 | LF |
| Sal Fasano | 54 | 5 | 6 | 0.261 | 0.340 | 0.348 | CR |
| Michael Aubrey | 50 | 2 | 3 | 0.200 | 0.280 | 0.333 | 1B |
| Josh Barfield | 33 | 3 | 2 | 0.182 | 0.182 | 0.212 | |
| Andy Gonzalez | 30 | 3 | 2 | 0.208 | 0.367 | 0.333 | |
| Jorge Velandia | 9 | 1 | 0 | 0.375 | 0.444 | 0.500 | |
| Jason Tyner | 3 | 0 | 0 | 0.000 | 0.333 | 0.000 |
| Name | IP | ERA | Gs | Gr | SO | WHIP |
|---|---|---|---|---|---|---|
| Cliff Lee | 223.0 | 2.54 | 31 | 0 | 170 | 1.11 |
| Paul Byrd | 131.0 | 4.53 | 22 | 0 | 56 | 1.30 |
| CC Sabathia | 122.0 | 3.83 | 18 | 0 | 123 | 1.23 |
| Jeremy Sowers | 121.0 | 5.58 | 22 | 0 | 64 | 1.49 |
| Roberto Hernandez | 120.3 | 5.44 | 22 | 0 | 58 | 1.62 |
| Aaron Laffey | 93.3 | 4.23 | 16 | 0 | 43 | 1.43 |
| Rafael Perez | 76.0 | 3.54 | 0 | 73 | 86 | 1.18 |
| Rafael Betancourt | 71.0 | 5.07 | 0 | 69 | 64 | 1.42 |
| Jensen Lewis | 66.0 | 3.82 | 0 | 51 | 52 | 1.44 |
| Masahide Kobayashi | 55.3 | 4.53 | 0 | 57 | 35 | 1.42 |
| Zach Jackson | 54.3 | 5.60 | 9 | 0 | 30 | 1.43 |
| Edward Mujica | 38.3 | 6.75 | 0 | 33 | 27 | 1.45 |
| Jake Westbrook | 34.3 | 3.12 | 5 | 0 | 19 | 1.15 |
| Anthony Reyes | 34.0 | 1.83 | 6 | 0 | 15 | 1.25 |
| Juan Rincon | 27.0 | 5.60 | 0 | 23 | 19 | 1.54 |
| Scott Lewis | 24.0 | 2.63 | 4 | 0 | 15 | 1.08 |
| Matt Ginter | 21.0 | 5.14 | 4 | 0 | 12 | 1.33 |
| Tom Mastny | 20.0 | 10.80 | 1 | 13 | 19 | 1.95 |
| Jorge Julio | 17.3 | 5.60 | 0 | 15 | 15 | 1.64 |
| Joe Borowski | 16.3 | 7.56 | 0 | 18 | 9 | 1.92 |
| Scott Elarton | 15.0 | 3.52 | 0 | 8 | 15 | 1.63 |
| Bryan Bullington | 14.3 | 4.91 | 2 | 1 | 12 | 1.16 |
| Brendan Donnelly | 13.3 | 8.56 | 0 | 15 | 8 | 2.19 |
| Craig Breslow | 8.0 | 3.24 | 0 | 7 | 7 | 1.80 |
| Rick Bauer | 6.0 | 13.50 | 0 | 4 | 4 | 2.17 |
| Rich Rundles | 5.0 | 1.80 | 0 | 8 | 6 | 1.60 |
| Jon Meloan | 2.0 | 0.00 | 0 | 2 | 2 | 0.50 |
| Brian Slocum | 2.0 | 27.00 | 0 | 2 | 1 | 4.00 |
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