| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 559 | 91 | 59 | 0.320 | 0.360 | 2.24 | 2B |
| Kevin Youkilis | 485 | 78 | 84 | 0.320 | 0.388 | 5.29 | 1B-3B |
| J.D. Drew | 451 | 79 | 64 | 0.280 | 0.408 | 4.12 | RF |
| Jacoby Ellsbury | 450 | 66 | 34 | 0.267 | 0.329 | -0.38 | CF-LF-RF |
| Mike Lowell | 427 | 52 | 67 | 0.270 | 0.335 | 2.18 | 3B |
| Manny Ramirez | 425 | 68 | 70 | 0.299 | 0.398 | 4.22 | LF |
| Jason Varitek | 374 | 26 | 32 | 0.215 | 0.305 | -2.95 | CR |
| David Ortiz | 336 | 50 | 62 | 0.260 | 0.363 | 3.64 | DH |
| Julio Lugo | 307 | 27 | 22 | 0.268 | 0.352 | -2.27 | SS |
| Coco Crisp | 302 | 35 | 28 | 0.246 | 0.295 | -0.68 | CF |
| Sean Casey | 174 | 13 | 12 | 0.348 | 0.408 | -1.58 | 1B-DH |
| Jed Lowrie | 153 | 14 | 30 | 0.318 | 0.373 | 0.92 | SS-3B |
| Kevin Cash | 121 | 8 | 11 | 0.218 | 0.281 | -0.93 | CR |
| Alex Cora | 95 | 5 | 6 | 0.296 | 0.389 | -1.14 | SS |
| Brandon Moss | 86 | 7 | 11 | 0.295 | 0.337 | -0.19 | LF-RF |
| Jason Bay | 68 | 15 | 12 | 0.328 | 0.397 | 1.19 | LF |
| Jeff Bailey | 12 | 2 | 1 | 0.222 | 0.417 | 0.02 | 1B |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.22 | X |
| Jonathan Van Every | 3 | 0 | 0 | 0.333 | 0.333 | -0.07 | X |
| Chris Carter | 3 | 1 | 0 | 0.667 | 0.667 | 0.03 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 160.7 | 3.25 | 25 | 0 | X | 3.92 |
| Josh Beckett | 149.3 | 4.34 | 23 | 0 | X | -0.16 |
| Tim Wakefield | 147.0 | 3.67 | 23 | 0 | X | 2.13 |
| Daisuke Matsuzaka | 121.7 | 2.74 | 21 | 0 | X | 4.42 |
| Clay Buchholz | 73.7 | 6.35 | 14 | 1 | X | -3.54 |
| Justin Masterson | 68.0 | 3.44 | 9 | 10 | X | 1.35 |
| Jonathan Papelbon | 52.3 | 1.89 | 0 | 51 | X | 2.93 |
| Manny Delcarmen | 51.0 | 4.24 | 0 | 54 | X | 0.07 |
| Hideki Okajima | 47.7 | 3.02 | 0 | 48 | X | 1.42 |
| Javier Lopez | 45.3 | 2.58 | 0 | 53 | X | 1.81 |
| David Aardsma | 42.3 | 3.83 | 0 | 41 | X | 0.46 |
| Mike Timlin | 35.3 | 5.35 | 0 | 37 | X | -0.87 |
| Bartolo Colon | 33.0 | 4.09 | 6 | 0 | X | 0.16 |
| Craig Hansen | 30.7 | 5.58 | 0 | 32 | X | -0.92 |
| Julian Tavarez | 12.7 | 6.39 | 0 | 9 | X | -0.62 |
| Chris Smith | 8.3 | 2.16 | 0 | 5 | X | 0.42 |
| Paul Byrd | 7.3 | 4.91 | 1 | 0 | X | -0.11 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.87 |
| David Pauley | 4.3 | 10.38 | 1 | 0 | X | -0.62 |
| Charlie Zink | 4.3 | 16.62 | 1 | 0 | X | -1.25 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.67 |
_