| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 599 | 101 | 69 | 0.317 | 0.359 | 3.46 | 2B |
| Kevin Youkilis | 524 | 81 | 91 | 0.318 | 0.387 | 5.47 | 1B-3B |
| Jacoby Ellsbury | 491 | 71 | 38 | 0.264 | 0.324 | -0.35 | CF-LF-RF |
| J.D. Drew | 451 | 79 | 64 | 0.280 | 0.408 | 4.18 | RF |
| Mike Lowell | 427 | 52 | 67 | 0.270 | 0.335 | 2.23 | 3B |
| Manny Ramirez | 425 | 68 | 70 | 0.299 | 0.398 | 4.28 | LF |
| Jason Varitek | 402 | 32 | 36 | 0.224 | 0.316 | -2.52 | CR |
| David Ortiz | 375 | 56 | 65 | 0.267 | 0.376 | 3.69 | DH |
| Coco Crisp | 336 | 40 | 32 | 0.263 | 0.315 | -0.51 | CF |
| Julio Lugo | 307 | 27 | 22 | 0.268 | 0.352 | -2.23 | SS |
| Jed Lowrie | 188 | 18 | 32 | 0.296 | 0.362 | 0.73 | SS-3B |
| Sean Casey | 182 | 13 | 12 | 0.345 | 0.407 | -1.75 | 1B-DH |
| Kevin Cash | 131 | 9 | 11 | 0.229 | 0.298 | -1.05 | CR |
| Alex Cora | 120 | 7 | 8 | 0.267 | 0.367 | -1.31 | SS |
| Jason Bay | 106 | 22 | 23 | 0.347 | 0.387 | 2.18 | LF |
| Brandon Moss | 86 | 7 | 11 | 0.295 | 0.337 | -0.18 | LF-RF |
| Jeff Bailey | 21 | 4 | 3 | 0.278 | 0.381 | 0.23 | 1B |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.22 | X |
| Jonathan Van Every | 3 | 0 | 0 | 0.333 | 0.333 | -0.07 | X |
| Chris Carter | 3 | 1 | 0 | 0.667 | 0.667 | 0.03 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 170.0 | 3.49 | 27 | 0 | X | 3.18 |
| Tim Wakefield | 152.0 | 3.73 | 24 | 0 | X | 2.01 |
| Josh Beckett | 149.3 | 4.34 | 23 | 0 | X | -0.15 |
| Daisuke Matsuzaka | 132.7 | 2.98 | 23 | 0 | X | 4.06 |
| Clay Buchholz | 76.0 | 6.75 | 15 | 1 | X | -4.35 |
| Justin Masterson | 73.0 | 3.21 | 9 | 14 | X | 1.86 |
| Jonathan Papelbon | 58.0 | 1.71 | 0 | 55 | X | 3.50 |
| Manny Delcarmen | 56.0 | 4.18 | 0 | 60 | X | 0.15 |
| Hideki Okajima | 52.0 | 2.77 | 0 | 52 | X | 1.85 |
| Javier Lopez | 49.3 | 2.92 | 0 | 57 | X | 1.59 |
| David Aardsma | 43.0 | 4.19 | 0 | 42 | X | 0.11 |
| Mike Timlin | 40.7 | 5.09 | 0 | 40 | X | -0.75 |
| Bartolo Colon | 33.0 | 4.09 | 6 | 0 | X | 0.16 |
| Craig Hansen | 30.7 | 5.58 | 0 | 32 | X | -0.92 |
| Paul Byrd | 19.3 | 4.66 | 3 | 0 | X | -0.16 |
| Julian Tavarez | 12.7 | 6.39 | 0 | 9 | X | -0.62 |
| Chris Smith | 10.7 | 5.06 | 0 | 6 | X | -0.19 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.87 |
| David Pauley | 4.3 | 10.38 | 1 | 0 | X | -0.62 |
| Charlie Zink | 4.3 | 16.62 | 1 | 0 | X | -1.25 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.67 |
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