| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 623 | 107 | 71 | 0.327 | 0.371 | 3.72 | 2B |
| Kevin Youkilis | 538 | 82 | 94 | 0.315 | 0.387 | 5.56 | 1B-3B |
| Jacoby Ellsbury | 515 | 75 | 40 | 0.267 | 0.326 | -0.30 | CF-LF-RF |
| J.D. Drew | 451 | 79 | 64 | 0.280 | 0.408 | 4.18 | RF |
| Mike Lowell | 427 | 52 | 67 | 0.270 | 0.335 | 2.24 | 3B |
| Manny Ramirez | 425 | 68 | 70 | 0.299 | 0.398 | 4.28 | LF |
| Jason Varitek | 418 | 33 | 38 | 0.226 | 0.316 | -2.59 | CR |
| David Ortiz | 399 | 59 | 66 | 0.267 | 0.381 | 3.54 | DH |
| Coco Crisp | 340 | 41 | 33 | 0.262 | 0.315 | -0.40 | CF |
| Julio Lugo | 307 | 27 | 22 | 0.268 | 0.352 | -2.23 | SS |
| Jed Lowrie | 212 | 20 | 37 | 0.280 | 0.349 | 0.89 | SS-3B |
| Sean Casey | 182 | 13 | 12 | 0.345 | 0.407 | -1.75 | 1B-DH |
| Alex Cora | 137 | 10 | 8 | 0.276 | 0.372 | -1.40 | SS |
| Kevin Cash | 134 | 9 | 11 | 0.231 | 0.299 | -1.12 | CR |
| Jason Bay | 128 | 23 | 28 | 0.313 | 0.359 | 2.28 | LF |
| Brandon Moss | 86 | 7 | 11 | 0.295 | 0.337 | -0.18 | LF-RF |
| Jeff Bailey | 33 | 8 | 5 | 0.286 | 0.394 | 0.57 | 1B |
| Mark Kotsay | 18 | 1 | 4 | 0.312 | 0.389 | 0.09 | RF |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.22 | X |
| Jonathan Van Every | 4 | 0 | 0 | 0.250 | 0.250 | -0.10 | X |
| Chris Carter | 3 | 1 | 0 | 0.667 | 0.667 | 0.03 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 176.7 | 3.41 | 28 | 0 | X | 3.65 |
| Tim Wakefield | 158.0 | 3.76 | 25 | 0 | X | 1.99 |
| Josh Beckett | 149.3 | 4.34 | 23 | 0 | X | -0.14 |
| Daisuke Matsuzaka | 140.7 | 2.82 | 24 | 0 | X | 4.87 |
| Clay Buchholz | 76.0 | 6.75 | 15 | 1 | X | -4.35 |
| Justin Masterson | 75.7 | 3.33 | 9 | 17 | X | 1.71 |
| Manny Delcarmen | 59.0 | 3.97 | 0 | 62 | X | 0.46 |
| Jonathan Papelbon | 59.0 | 1.68 | 0 | 57 | X | 3.61 |
| Hideki Okajima | 54.0 | 2.83 | 0 | 54 | X | 1.85 |
| Javier Lopez | 51.3 | 2.81 | 0 | 59 | X | 1.79 |
| David Aardsma | 43.0 | 4.19 | 0 | 42 | X | 0.11 |
| Mike Timlin | 41.7 | 4.97 | 0 | 41 | X | -0.65 |
| Bartolo Colon | 33.0 | 4.09 | 6 | 0 | X | 0.16 |
| Craig Hansen | 30.7 | 5.58 | 0 | 32 | X | -0.91 |
| Paul Byrd | 26.3 | 4.78 | 4 | 0 | X | -0.30 |
| Julian Tavarez | 12.7 | 6.39 | 0 | 9 | X | -0.62 |
| Chris Smith | 10.7 | 5.06 | 0 | 6 | X | -0.19 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.87 |
| Michael Bowden | 5.0 | 3.60 | 1 | 0 | X | 0.08 |
| Charlie Zink | 4.3 | 16.62 | 1 | 0 | X | -1.25 |
| David Pauley | 4.3 | 10.38 | 1 | 0 | X | -0.62 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.67 |
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