| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 655 | 112 | 78 | 0.327 | 0.371 | 4.19 | 2B |
| Kevin Youkilis | 553 | 84 | 99 | 0.315 | 0.387 | 5.91 | 1B-3B |
| Jacoby Ellsbury | 536 | 77 | 43 | 0.263 | 0.325 | -0.30 | CF-LF-RF |
| J.D. Drew | 451 | 79 | 64 | 0.280 | 0.408 | 4.16 | RF |
| Jason Varitek | 443 | 35 | 38 | 0.225 | 0.314 | -2.99 | CR |
| Mike Lowell | 443 | 55 | 72 | 0.277 | 0.339 | 2.68 | 3B |
| David Ortiz | 426 | 65 | 73 | 0.268 | 0.378 | 4.24 | DH |
| Manny Ramirez | 425 | 68 | 70 | 0.299 | 0.398 | 4.26 | LF |
| Coco Crisp | 370 | 48 | 38 | 0.290 | 0.341 | 0.13 | CF |
| Julio Lugo | 307 | 27 | 22 | 0.268 | 0.352 | -2.24 | SS |
| Jed Lowrie | 239 | 25 | 40 | 0.272 | 0.351 | 1.07 | SS-3B |
| Sean Casey | 188 | 14 | 13 | 0.345 | 0.404 | -1.69 | 1B-DH |
| Jason Bay | 154 | 30 | 32 | 0.314 | 0.370 | 2.80 | LF |
| Alex Cora | 151 | 12 | 9 | 0.295 | 0.384 | -1.43 | SS |
| Kevin Cash | 139 | 10 | 11 | 0.230 | 0.295 | -1.14 | CR |
| Brandon Moss | 86 | 7 | 11 | 0.295 | 0.337 | -0.18 | LF-RF |
| Mark Kotsay | 44 | 4 | 9 | 0.275 | 0.341 | 0.31 | RF |
| Jeff Bailey | 42 | 10 | 6 | 0.286 | 0.405 | 0.67 | 1B |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.22 | X |
| Jonathan Van Every | 6 | 0 | 1 | 0.333 | 0.333 | -0.04 | X |
| Chris Carter | 3 | 1 | 0 | 0.667 | 0.667 | 0.03 | X |
| David Ross | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | CR |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 189.3 | 3.23 | 30 | 0 | X | 4.79 |
| Tim Wakefield | 159.7 | 4.11 | 26 | 0 | X | 0.75 |
| Josh Beckett | 154.3 | 4.20 | 24 | 0 | X | 0.42 |
| Daisuke Matsuzaka | 151.7 | 2.97 | 26 | 0 | X | 4.78 |
| Justin Masterson | 78.7 | 3.20 | 9 | 19 | X | 2.04 |
| Clay Buchholz | 76.0 | 6.75 | 15 | 1 | X | -4.32 |
| Manny Delcarmen | 64.7 | 3.76 | 0 | 66 | X | 0.84 |
| Jonathan Papelbon | 62.0 | 1.89 | 0 | 60 | X | 3.51 |
| Hideki Okajima | 55.3 | 2.93 | 0 | 56 | X | 1.79 |
| Javier Lopez | 54.0 | 2.67 | 0 | 63 | X | 2.08 |
| Mike Timlin | 43.7 | 5.56 | 0 | 42 | X | -1.27 |
| David Aardsma | 43.0 | 4.19 | 0 | 42 | X | 0.13 |
| Paul Byrd | 33.0 | 3.82 | 5 | 0 | X | 0.38 |
| Bartolo Colon | 33.0 | 4.09 | 6 | 0 | X | 0.17 |
| Craig Hansen | 30.7 | 5.58 | 0 | 32 | X | -0.90 |
| Chris Smith | 14.0 | 5.79 | 0 | 9 | X | -0.48 |
| Julian Tavarez | 12.7 | 6.39 | 0 | 9 | X | -0.61 |
| David Pauley | 8.3 | 8.64 | 1 | 2 | X | -0.84 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.87 |
| Michael Bowden | 5.0 | 3.60 | 1 | 0 | X | 0.08 |
| Charlie Zink | 4.3 | 16.62 | 1 | 0 | X | -1.24 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.67 |
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