| Name | PA | R | RBI | BA | OBP | SLG | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 714 | 115 | 72 | 0.296 | 0.371 | 0.447 | 2B |
| Jacoby Ellsbury | 693 | 94 | 60 | 0.301 | 0.355 | 0.415 | CF |
| Jason Bay | 638 | 103 | 119 | 0.267 | 0.384 | 0.537 | LF |
| David Ortiz | 627 | 77 | 99 | 0.238 | 0.332 | 0.462 | DH |
| Kevin Youkilis | 588 | 99 | 94 | 0.305 | 0.413 | 0.548 | 1B-3B |
| J.D. Drew | 539 | 84 | 68 | 0.279 | 0.392 | 0.522 | RF |
| Mike Lowell | 484 | 54 | 75 | 0.290 | 0.337 | 0.474 | 3B |
| Jason Varitek | 425 | 41 | 51 | 0.209 | 0.313 | 0.390 | CR |
| Nick Green | 309 | 35 | 35 | 0.236 | 0.303 | 0.366 | SS |
| Victor Martinez | 237 | 32 | 41 | 0.336 | 0.405 | 0.507 | CR-1B |
| Rocco Baldelli | 164 | 23 | 23 | 0.253 | 0.311 | 0.433 | RF |
| Alex Gonzalez | 159 | 26 | 15 | 0.284 | 0.316 | 0.453 | SS |
| Julio Lugo | 123 | 16 | 8 | 0.284 | 0.352 | 0.367 | SS |
| George Kottaras | 107 | 15 | 10 | 0.237 | 0.308 | 0.387 | CR |
| Casey Kotchman | 95 | 9 | 7 | 0.218 | 0.284 | 0.287 | 1B |
| Jeff Bailey | 91 | 14 | 9 | 0.208 | 0.330 | 0.416 | 1B |
| Mark Kotsay | 79 | 4 | 5 | 0.257 | 0.291 | 0.324 | 1B |
| Jed Lowrie | 76 | 5 | 11 | 0.147 | 0.211 | 0.265 | SS |
| Josh Reddick | 62 | 5 | 4 | 0.169 | 0.210 | 0.339 | LF-RF |
| Brian Anderson | 21 | 7 | 5 | 0.294 | 0.381 | 0.647 | RF |
| Adam LaRoche | 19 | 2 | 3 | 0.263 | 0.263 | 0.526 | |
| Joey Gathright | 17 | 7 | 0 | 0.313 | 0.353 | 0.313 | |
| Chris Woodward | 16 | 0 | 0 | 0.083 | 0.313 | 0.083 | |
| Jonathan Van Every | 13 | 1 | 3 | 0.364 | 0.462 | 0.636 | |
| Aaron Bates | 12 | 2 | 2 | 0.364 | 0.417 | 0.545 | |
| Chris Carter | 6 | 0 | 1 | 0.000 | 0.000 | 0.000 | |
| Dusty Brown | 4 | 1 | 1 | 0.333 | 0.500 | 1.333 | |
| Gil Velazquez | 3 | 0 | 0 | 0.000 | 0.333 | 0.000 |
| Name | IP | ERA | Gs | Gr | SO | WHIP |
|---|---|---|---|---|---|---|
| Josh Beckett | 212.0 | 3.86 | 32 | 0 | 199 | 1.19 |
| Jon Lester | 203.0 | 3.41 | 32 | 0 | 225 | 1.23 |
| Brad Penny | 131.3 | 5.61 | 24 | 0 | 89 | 1.53 |
| Tim Wakefield | 129.3 | 4.58 | 21 | 0 | 72 | 1.44 |
| Clay Buchholz | 92.0 | 4.21 | 16 | 0 | 68 | 1.38 |
| Justin Masterson | 72.0 | 4.50 | 6 | 25 | 67 | 1.35 |
| Ramon Ramirez | 69.3 | 2.84 | 0 | 70 | 52 | 1.33 |
| Jonathan Papelbon | 68.0 | 1.85 | 0 | 66 | 76 | 1.15 |
| Hideki Okajima | 61.0 | 3.39 | 0 | 68 | 53 | 1.26 |
| Manny Delcarmen | 59.3 | 4.53 | 0 | 64 | 44 | 1.64 |
| Daisuke Matsuzaka | 59.0 | 5.76 | 12 | 0 | 54 | 1.87 |
| Takashi Saito | 55.3 | 2.43 | 0 | 56 | 52 | 1.35 |
| Daniel Bard | 49.0 | 3.65 | 0 | 49 | 63 | 1.28 |
| John Smoltz | 40.0 | 8.33 | 8 | 0 | 33 | 1.70 |
| Paul Byrd | 34.0 | 5.82 | 6 | 1 | 11 | 1.71 |
| Junichi Tazawa | 25.0 | 7.46 | 4 | 2 | 13 | 2.05 |
| Michael Bowden | 16.0 | 9.56 | 1 | 7 | 12 | 1.81 |
| Billy Wagner | 13.3 | 1.98 | 0 | 15 | 22 | 1.10 |
| Hunter Jones | 12.3 | 9.24 | 0 | 11 | 9 | 1.82 |
| Javier Lopez | 11.3 | 9.26 | 0 | 14 | 5 | 2.49 |
| Fernando Cabrera | 5.0 | 8.44 | 0 | 6 | 8 | 2.06 |
| Enrique Gonzalez | 3.3 | 4.91 | 0 | 2 | 1 | 1.91 |
| Billy Traber | 3.3 | 12.27 | 0 | 1 | 1 | 2.73 |
| Dustin Richardson | 3.0 | 0.00 | 0 | 3 | 0 | 1.20 |
| Nick Green | 2.0 | 0.00 | 0 | 1 | 0 | 1.50 |
| Dusty Brown | 1.0 | 9.00 | 0 | 1 | 1 | 2.00 |
| Jonathan Van Every | 0.3 | 0.00 | 0 | 1 | 0 | 3.00 |
_