| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 137 | 27 | 11 | 0.316 | 0.409 | 0.59 | 2B |
| David Ortiz | 128 | 11 | 14 | 0.226 | 0.336 | -0.55 | DH |
| Jason Bay | 126 | 26 | 29 | 0.316 | 0.476 | 2.65 | LF |
| Jacoby Ellsbury | 125 | 16 | 9 | 0.288 | 0.320 | -0.48 | CF |
| Mike Lowell | 119 | 17 | 26 | 0.292 | 0.328 | 1.56 | 3B |
| Kevin Youkilis | 109 | 23 | 20 | 0.393 | 0.505 | 1.81 | 1B-3B |
| J.D. Drew | 106 | 15 | 14 | 0.250 | 0.377 | 0.41 | RF |
| Jason Varitek | 91 | 10 | 11 | 0.231 | 0.330 | -0.06 | CR |
| Nick Green | 79 | 9 | 11 | 0.278 | 0.342 | 0.14 | SS |
| George Kottaras | 30 | 3 | 3 | 0.160 | 0.267 | -0.12 | CR |
| Jeff Bailey | 29 | 4 | 7 | 0.167 | 0.310 | 0.43 | 1B |
| Julio Lugo | 22 | 4 | 1 | 0.350 | 0.409 | -0.02 | 2B-SS |
| Jed Lowrie | 20 | 0 | 0 | 0.056 | 0.150 | -0.50 | SS |
| Rocco Baldelli | 18 | 3 | 3 | 0.235 | 0.278 | 0.18 | RF |
| Jonathan Van Every | 13 | 1 | 3 | 0.364 | 0.462 | 0.10 | X |
| Chris Carter | 6 | 0 | 1 | 0.000 | 0.000 | -0.04 | X |
| Gil Velazquez | 2 | 0 | 0 | 0.000 | 0.000 | -0.05 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Tim Wakefield | 40.0 | 2.92 | 6 | 0 | X | 1.49 |
| Jon Lester | 37.0 | 5.11 | 6 | 0 | X | -0.51 |
| Josh Beckett | 34.7 | 6.75 | 6 | 0 | X | -1.80 |
| Justin Masterson | 29.0 | 5.28 | 4 | 4 | X | -0.51 |
| Brad Penny | 23.7 | 7.61 | 5 | 0 | X | -1.70 |
| Manny Delcarmen | 15.3 | 0.59 | 0 | 13 | X | 1.41 |
| Ramon Ramirez | 15.3 | 0.59 | 0 | 14 | X | 1.41 |
| Hideki Okajima | 13.7 | 3.95 | 0 | 14 | X | 0.18 |
| Jonathan Papelbon | 12.0 | 1.50 | 0 | 11 | X | 0.85 |
| Takashi Saito | 11.0 | 4.09 | 0 | 11 | X | 0.11 |
| Javier Lopez | 9.7 | 10.24 | 0 | 13 | X | -1.29 |
| Hunter Jones | 8.0 | 3.38 | 0 | 6 | X | 0.21 |
| Daisuke Matsuzaka | 6.3 | 12.79 | 2 | 0 | X | -1.22 |
| Michael Bowden | 2.0 | 0.00 | 0 | 1 | X | 0.21 |
| Jonathan Van Every | 0.7 | 0.00 | 0 | 1 | X | 0.07 |
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