| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 571 | 91 | 59 | 0.302 | 0.373 | 1.89 | 2B |
| Jacoby Ellsbury | 553 | 70 | 47 | 0.299 | 0.344 | -1.14 | CF |
| Jason Bay | 524 | 84 | 94 | 0.258 | 0.384 | 5.97 | LF |
| David Ortiz | 505 | 62 | 79 | 0.228 | 0.319 | 2.55 | DH |
| Kevin Youkilis | 473 | 80 | 74 | 0.306 | 0.416 | 4.69 | 1B-3B |
| J.D. Drew | 452 | 71 | 52 | 0.265 | 0.383 | 1.94 | RF |
| Mike Lowell | 403 | 48 | 65 | 0.299 | 0.342 | 2.08 | 3B |
| Jason Varitek | 372 | 39 | 49 | 0.222 | 0.331 | 0.21 | CR |
| Nick Green | 302 | 34 | 35 | 0.233 | 0.298 | -0.09 | SS |
| Rocco Baldelli | 131 | 18 | 20 | 0.263 | 0.328 | 0.81 | RF |
| Julio Lugo | 123 | 16 | 8 | 0.284 | 0.350 | -0.47 | 2B-SS |
| Victor Martinez | 118 | 15 | 19 | 0.308 | 0.381 | 0.71 | CR-1B |
| George Kottaras | 99 | 14 | 9 | 0.224 | 0.303 | 0.01 | CR |
| Jeff Bailey | 91 | 14 | 10 | 0.208 | 0.330 | 0.31 | 1B |
| Mark Kotsay | 79 | 5 | 5 | 0.257 | 0.291 | -0.87 | 1B |
| Jed Lowrie | 63 | 2 | 7 | 0.143 | 0.206 | -0.58 | SS |
| Alex Gonzalez | 52 | 8 | 7 | 0.269 | 0.269 | 0.31 | SS |
| Casey Kotchman | 41 | 6 | 5 | 0.216 | 0.293 | 0.16 | 1B |
| Josh Reddick | 33 | 2 | 2 | 0.188 | 0.212 | -0.38 | LF-RF |
| Adam LaRoche | 19 | 2 | 3 | 0.263 | 0.263 | 0.06 | 1B |
| Jonathan Van Every | 13 | 1 | 3 | 0.364 | 0.462 | 0.10 | X |
| Aaron Bates | 12 | 1 | 2 | 0.364 | 0.417 | 0.02 | X |
| Brian Anderson | 7 | 0 | 1 | 0.167 | 0.143 | -0.06 | CF |
| Chris Woodward | 7 | 0 | 0 | 0.000 | 0.429 | -0.17 | 3B |
| Chris Carter | 6 | 0 | 1 | 0.000 | 0.000 | -0.04 | X |
| Gil Velazquez | 3 | 0 | 0 | 0.000 | 0.333 | -0.07 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Josh Beckett | 175.3 | 3.80 | 26 | 0 | X | 2.15 |
| Jon Lester | 167.7 | 3.60 | 26 | 0 | X | 2.85 |
| Brad Penny | 131.7 | 5.61 | 24 | 0 | X | -3.94 |
| Tim Wakefield | 115.7 | 4.12 | 18 | 0 | X | 0.54 |
| Justin Masterson | 72.0 | 4.25 | 6 | 25 | X | 0.12 |
| Ramon Ramirez | 57.3 | 2.67 | 0 | 57 | X | 2.21 |
| Jonathan Papelbon | 55.7 | 1.94 | 0 | 55 | X | 3.10 |
| Hideki Okajima | 53.7 | 2.85 | 0 | 59 | X | 1.84 |
| Manny Delcarmen | 51.7 | 3.66 | 0 | 53 | X | 0.80 |
| Clay Buchholz | 51.3 | 4.38 | 9 | 0 | X | -0.07 |
| Takashi Saito | 46.0 | 2.74 | 0 | 46 | X | 1.70 |
| Daniel Bard | 41.3 | 3.48 | 0 | 37 | X | 0.81 |
| John Smoltz | 40.0 | 8.10 | 8 | 0 | X | -3.52 |
| Daisuke Matsuzaka | 35.0 | 8.23 | 8 | 0 | X | -3.19 |
| Junichi Tazawa | 21.7 | 6.65 | 4 | 1 | X | -1.17 |
| Javier Lopez | 11.7 | 9.26 | 0 | 14 | X | -1.34 |
| Hunter Jones | 9.0 | 8.00 | 0 | 8 | X | -0.77 |
| Michael Bowden | 4.0 | 15.75 | 0 | 2 | X | -1.07 |
| Fernando Cabrera | 4.0 | 4.50 | 0 | 4 | X | -0.02 |
| Billy Traber | 3.7 | 14.73 | 0 | 1 | X | -0.89 |
| Enrique Gonzalez | 3.7 | 4.91 | 0 | 2 | X | -0.05 |
| Nick Green | 2.0 | 0.00 | 0 | 1 | X | 0.20 |
| Jonathan Van Every | 0.7 | 0.00 | 0 | 1 | X | 0.07 |
_