| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 644 | 101 | 66 | 0.294 | 0.363 | 1.96 | 2B |
| Jacoby Ellsbury | 627 | 81 | 53 | 0.301 | 0.348 | -1.09 | CF |
| Jason Bay | 585 | 95 | 109 | 0.266 | 0.386 | 7.27 | LF |
| David Ortiz | 567 | 71 | 84 | 0.230 | 0.325 | 2.56 | DH |
| Kevin Youkilis | 528 | 91 | 85 | 0.311 | 0.419 | 5.71 | 1B-3B |
| J.D. Drew | 503 | 79 | 58 | 0.265 | 0.384 | 2.22 | RF |
| Mike Lowell | 445 | 54 | 70 | 0.292 | 0.335 | 2.26 | 3B |
| Jason Varitek | 404 | 40 | 52 | 0.212 | 0.317 | -0.11 | CR |
| Nick Green | 309 | 34 | 36 | 0.236 | 0.301 | -0.12 | SS |
| Victor Martinez | 177 | 21 | 30 | 0.331 | 0.401 | 1.07 | CR-1B |
| Rocco Baldelli | 150 | 21 | 23 | 0.255 | 0.313 | 0.99 | RF |
| Julio Lugo | 123 | 16 | 8 | 0.284 | 0.350 | -0.45 | 2B-SS |
| Alex Gonzalez | 109 | 17 | 15 | 0.286 | 0.284 | 0.72 | SS |
| George Kottaras | 101 | 14 | 10 | 0.230 | 0.307 | 0.08 | CR |
| Jeff Bailey | 91 | 14 | 10 | 0.208 | 0.330 | 0.32 | 1B |
| Mark Kotsay | 79 | 5 | 5 | 0.257 | 0.291 | -0.86 | 1B |
| Casey Kotchman | 64 | 6 | 7 | 0.237 | 0.297 | -0.18 | 1B |
| Jed Lowrie | 64 | 2 | 7 | 0.158 | 0.219 | -0.60 | SS |
| Josh Reddick | 42 | 4 | 2 | 0.225 | 0.262 | -0.39 | LF-RF |
| Adam LaRoche | 19 | 2 | 3 | 0.263 | 0.263 | 0.07 | 1B |
| Jonathan Van Every | 13 | 1 | 3 | 0.364 | 0.462 | 0.11 | X |
| Aaron Bates | 12 | 1 | 2 | 0.364 | 0.417 | 0.02 | X |
| Chris Woodward | 10 | 0 | 0 | 0.000 | 0.300 | -0.24 | 3B |
| Brian Anderson | 9 | 0 | 1 | 0.125 | 0.111 | -0.11 | CF |
| Chris Carter | 6 | 0 | 1 | 0.000 | 0.000 | -0.04 | X |
| Gil Velazquez | 3 | 0 | 0 | 0.000 | 0.333 | -0.07 | X |
| Joey Gathright | 3 | 1 | 0 | 0.333 | 0.333 | 0.03 | CF |
| Dusty Brown | 1 | 0 | 0 | 0.000 | 0.000 | -0.02 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Josh Beckett | 201.3 | 3.80 | 30 | 0 | X | 2.40 |
| Jon Lester | 188.7 | 3.29 | 29 | 0 | X | 4.49 |
| Brad Penny | 131.7 | 5.61 | 24 | 0 | X | -3.98 |
| Tim Wakefield | 121.7 | 4.22 | 19 | 0 | X | 0.27 |
| Clay Buchholz | 77.3 | 3.49 | 13 | 0 | X | 1.48 |
| Justin Masterson | 72.0 | 4.25 | 6 | 25 | X | 0.10 |
| Jonathan Papelbon | 64.0 | 1.97 | 0 | 62 | X | 3.50 |
| Ramon Ramirez | 61.3 | 2.79 | 0 | 62 | X | 2.18 |
| Hideki Okajima | 58.0 | 3.41 | 0 | 65 | X | 1.21 |
| Manny Delcarmen | 55.3 | 3.74 | 0 | 58 | X | 0.74 |
| Takashi Saito | 49.7 | 2.54 | 0 | 50 | X | 2.06 |
| Daniel Bard | 45.7 | 3.35 | 0 | 43 | X | 1.02 |
| Daisuke Matsuzaka | 41.0 | 7.02 | 9 | 0 | X | -2.60 |
| John Smoltz | 40.0 | 8.10 | 8 | 0 | X | -3.54 |
| Junichi Tazawa | 25.3 | 7.46 | 4 | 2 | X | -1.86 |
| Paul Byrd | 18.7 | 5.79 | 4 | 0 | X | -0.64 |
| Javier Lopez | 11.7 | 9.26 | 0 | 14 | X | -1.35 |
| Hunter Jones | 9.0 | 8.00 | 0 | 8 | X | -0.77 |
| Billy Wagner | 7.3 | 2.45 | 0 | 8 | X | 0.32 |
| Michael Bowden | 6.0 | 10.50 | 0 | 3 | X | -0.87 |
| Fernando Cabrera | 4.0 | 4.50 | 0 | 4 | X | -0.02 |
| Enrique Gonzalez | 3.7 | 4.91 | 0 | 2 | X | -0.05 |
| Billy Traber | 3.7 | 14.73 | 0 | 1 | X | -0.89 |
| Nick Green | 2.0 | 0.00 | 0 | 1 | X | 0.20 |
| Jonathan Van Every | 0.7 | 0.00 | 0 | 1 | X | 0.07 |
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