| Name | PA | R | RBI | BA | OBP | SLG | POS |
|---|---|---|---|---|---|---|---|
| Marco Scutaro | 695 | 92 | 56 | 0.275 | 0.333 | 0.388 | SS-2B |
| Adrian Beltre | 641 | 84 | 102 | 0.321 | 0.365 | 0.553 | 3B |
| David Ortiz | 606 | 86 | 102 | 0.270 | 0.370 | 0.529 | DH |
| J.D. Drew | 546 | 69 | 68 | 0.255 | 0.341 | 0.452 | RF |
| Victor Martinez | 538 | 64 | 79 | 0.302 | 0.351 | 0.493 | CR-1B |
| Kevin Youkilis | 435 | 77 | 62 | 0.307 | 0.411 | 0.564 | 1B |
| Bill Hall | 382 | 44 | 46 | 0.247 | 0.316 | 0.456 | LF-2B |
| Darnell McDonald | 363 | 40 | 34 | 0.270 | 0.336 | 0.429 | CF-RF-LF |
| Dustin Pedroia | 351 | 53 | 41 | 0.288 | 0.367 | 0.493 | 2B |
| Mike Lowell | 244 | 23 | 26 | 0.239 | 0.307 | 0.367 | 1B-DH |
| Jed Lowrie | 197 | 31 | 24 | 0.287 | 0.381 | 0.526 | 2B-SS |
| Daniel Nava | 188 | 23 | 26 | 0.242 | 0.351 | 0.360 | LF |
| Mike Cameron | 180 | 24 | 15 | 0.259 | 0.328 | 0.401 | CF |
| Ryan Kalish | 179 | 26 | 24 | 0.252 | 0.305 | 0.405 | CF-LF |
| Jeremy Hermida | 171 | 14 | 27 | 0.203 | 0.257 | 0.348 | LF |
| Jason Varitek | 123 | 18 | 16 | 0.232 | 0.293 | 0.473 | CR |
| Eric Patterson | 93 | 13 | 7 | 0.226 | 0.293 | 0.405 | LF-CF |
| Jacoby Ellsbury | 84 | 10 | 5 | 0.192 | 0.241 | 0.244 | CF |
| Kevin Cash | 68 | 1 | 1 | 0.133 | 0.224 | 0.150 | CR |
| Josh Reddick | 63 | 5 | 5 | 0.194 | 0.206 | 0.323 | RF |
| Yamaico Navarro | 46 | 4 | 5 | 0.143 | 0.174 | 0.143 | SS |
| Lars Anderson | 43 | 4 | 4 | 0.200 | 0.326 | 0.229 | 1B |
| Jarrod Saltalamacchia | 25 | 2 | 1 | 0.158 | 0.360 | 0.316 | |
| Jonathan Van Every | 21 | 6 | 1 | 0.211 | 0.286 | 0.421 | CF |
| Felipe Lopez | 16 | 2 | 1 | 0.267 | 0.313 | 0.467 | |
| Dusty Brown | 12 | 0 | 2 | 0.250 | 0.250 | 0.333 | |
| Gustavo Molina | 7 | 1 | 0 | 0.143 | 0.143 | 0.143 | |
| Ryan Shealy | 7 | 0 | 0 | 0.000 | 0.000 | 0.000 | |
| Niuman Romero | 4 | 1 | 0 | 0.000 | 0.000 | 0.000 | |
| Angel Sanchez | 3 | 0 | 0 | 0.000 | 0.000 | 0.000 |
| Name | IP | ERA | Gs | Gr | SO | WHIP |
|---|---|---|---|---|---|---|
| John Lackey | 215.0 | 4.40 | 33 | 0 | 156 | 1.42 |
| Jon Lester | 208.0 | 3.25 | 32 | 0 | 225 | 1.20 |
| Clay Buchholz | 173.3 | 2.33 | 28 | 0 | 120 | 1.20 |
| Daisuke Matsuzaka | 153.3 | 4.69 | 25 | 0 | 133 | 1.37 |
| Tim Wakefield | 140.0 | 5.34 | 19 | 13 | 84 | 1.35 |
| Josh Beckett | 127.3 | 5.78 | 21 | 0 | 116 | 1.53 |
| Daniel Bard | 74.3 | 1.93 | 0 | 73 | 76 | 1.00 |
| Jonathan Papelbon | 67.0 | 3.90 | 0 | 65 | 76 | 1.27 |
| Scott Atchison | 60.0 | 4.50 | 1 | 42 | 41 | 1.28 |
| Hideki Okajima | 46.0 | 4.50 | 0 | 56 | 33 | 1.72 |
| Manny Delcarmen | 44.0 | 4.70 | 0 | 48 | 32 | 1.39 |
| Ramon Ramirez | 42.0 | 4.46 | 0 | 44 | 31 | 1.30 |
| Felix Doubront | 25.0 | 4.32 | 3 | 9 | 23 | 1.48 |
| Michael Bowden | 15.0 | 4.70 | 0 | 14 | 13 | 1.56 |
| Scott Schoeneweis | 13.3 | 7.90 | 0 | 15 | 13 | 2.12 |
| Dustin Richardson | 13.0 | 4.15 | 0 | 26 | 12 | 2.23 |
| Robert Manuel | 12.3 | 4.26 | 0 | 10 | 5 | 1.34 |
| Joe Nelson | 8.0 | 9.72 | 0 | 8 | 9 | 2.40 |
| Robert Coello | 5.3 | 4.76 | 0 | 6 | 5 | 1.59 |
| Rich Hill | 4.0 | 0.00 | 0 | 6 | 3 | 1.50 |
| Boof Bonser | 2.0 | 18.00 | 0 | 2 | 0 | 4.00 |
| Matt Fox | 1.3 | 10.80 | 0 | 3 | 0 | 3.00 |
| Fernando Cabrera | 1.0 | 20.25 | 0 | 1 | 0 | 3.00 |
| Bill Hall | 1.0 | 0.00 | 0 | 1 | 0 | 0.00 |
| Jonathan Van Every | 1.0 | 18.00 | 0 | 1 | 1 | 2.00 |
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