| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 340 | 51 | 42 | 0.293 | 0.368 | 1.88 | 2B |
| Marco Scutaro | 336 | 45 | 24 | 0.283 | 0.348 | -0.55 | SS-2B |
| Kevin Youkilis | 299 | 58 | 47 | 0.306 | 0.428 | 4.09 | 1B |
| Adrian Beltre | 296 | 36 | 51 | 0.342 | 0.382 | 2.27 | 3B |
| J.D. Drew | 260 | 40 | 36 | 0.274 | 0.358 | 1.95 | RF |
| Victor Martinez | 259 | 36 | 37 | 0.295 | 0.347 | 1.66 | CR-1B |
| David Ortiz | 248 | 38 | 46 | 0.252 | 0.355 | 3.07 | DH |
| Darnell McDonald | 174 | 18 | 20 | 0.273 | 0.322 | -0.05 | CF-RF-LF |
| Jeremy Hermida | 149 | 13 | 27 | 0.217 | 0.268 | 0.74 | RF |
| Bill Hall | 136 | 18 | 16 | 0.235 | 0.324 | 0.42 | LF-2B |
| Mike Cameron | 97 | 11 | 5 | 0.261 | 0.330 | -0.57 | CF |
| Jason Varitek | 95 | 17 | 14 | 0.267 | 0.337 | 1.05 | CR |
| Mike Lowell | 91 | 5 | 13 | 0.212 | 0.308 | -0.22 | 1B-DH |
| Jacoby Ellsbury | 45 | 7 | 3 | 0.250 | 0.267 | 0.01 | CF |
| Daniel Nava | 44 | 8 | 10 | 0.350 | 0.409 | 0.87 | LF |
| Josh Reddick | 26 | 2 | 3 | 0.160 | 0.192 | -0.08 | RF |
| Jonathan Van Every | 21 | 5 | 1 | 0.211 | 0.286 | 0.14 | CF |
| Angel Sanchez | 3 | 0 | 0 | 0.000 | 0.000 | -0.07 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 98.0 | 3.03 | 15 | 0 | X | 2.45 |
| John Lackey | 94.0 | 4.69 | 15 | 0 | X | -1.30 |
| Clay Buchholz | 91.0 | 2.47 | 14 | 0 | X | 3.46 |
| Tim Wakefield | 79.3 | 5.33 | 11 | 4 | X | -2.28 |
| Daisuke Matsuzaka | 54.0 | 4.50 | 9 | 0 | X | -0.50 |
| Josh Beckett | 45.7 | 7.29 | 8 | 0 | X | -3.40 |
| Daniel Bard | 38.3 | 2.11 | 0 | 37 | X | 1.78 |
| Manny Delcarmen | 32.3 | 3.06 | 0 | 31 | X | 0.78 |
| Jonathan Papelbon | 31.7 | 3.98 | 0 | 30 | X | 0.09 |
| Ramon S. Ramirez | 27.7 | 4.88 | 0 | 30 | X | -0.50 |
| Hideki Okajima | 24.7 | 5.47 | 0 | 31 | X | -0.79 |
| Scott Atchison | 21.7 | 4.15 | 1 | 11 | X | -0.03 |
| Scott Schoeneweis | 13.7 | 7.90 | 0 | 15 | X | -1.21 |
| Joe Nelson | 8.3 | 9.72 | 0 | 8 | X | -1.09 |
| Felix Doubront | 5.0 | 5.40 | 1 | 0 | X | -0.15 |
| Boof Bonser | 2.0 | 18.00 | 0 | 2 | X | -0.65 |
| Jonathan Van Every | 1.0 | 18.00 | 0 | 1 | X | -0.32 |
| Dustin Richardson | 1.0 | 9.00 | 0 | 3 | X | -0.11 |
| Bill Hall | 1.0 | 0.00 | 0 | 1 | X | 0.10 |
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