| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Marco Scutaro | 616 | 76 | 49 | 0.272 | 0.330 | -1.12 | SS-2B |
| Adrian Beltre | 547 | 70 | 92 | 0.320 | 0.360 | 4.36 | 3B |
| David Ortiz | 512 | 72 | 82 | 0.259 | 0.361 | 4.33 | DH |
| J.D. Drew | 479 | 62 | 59 | 0.253 | 0.344 | 1.63 | RF |
| Kevin Youkilis | 435 | 77 | 62 | 0.307 | 0.411 | 4.54 | 1B |
| Victor Martinez | 432 | 49 | 55 | 0.289 | 0.336 | 0.93 | CR-1B |
| Dustin Pedroia | 351 | 52 | 42 | 0.288 | 0.365 | 1.75 | 2B |
| Bill Hall | 314 | 38 | 40 | 0.246 | 0.309 | 0.93 | LF-2B |
| Darnell McDonald | 308 | 32 | 32 | 0.268 | 0.328 | -0.40 | CF-RF-LF |
| Mike Lowell | 195 | 16 | 22 | 0.240 | 0.308 | -0.52 | 1B-DH |
| Mike Cameron | 180 | 24 | 15 | 0.259 | 0.328 | -0.07 | CF |
| Jeremy Hermida | 171 | 14 | 27 | 0.203 | 0.257 | 0.35 | RF |
| Daniel Nava | 142 | 18 | 20 | 0.248 | 0.338 | 0.71 | LF |
| Jed Lowrie | 108 | 16 | 11 | 0.272 | 0.380 | 0.34 | 2B-SS |
| Jason Varitek | 105 | 17 | 16 | 0.263 | 0.324 | 1.04 | CR |
| Ryan Kalish | 94 | 13 | 10 | 0.233 | 0.277 | 0.24 | CF-LF |
| Jacoby Ellsbury | 84 | 10 | 5 | 0.190 | 0.238 | -0.37 | CF |
| Eric Patterson | 74 | 9 | 6 | 0.254 | 0.311 | -0.14 | LF |
| Kevin Cash | 62 | 1 | 0 | 0.143 | 0.226 | -1.33 | CR |
| Josh Reddick | 26 | 2 | 3 | 0.160 | 0.192 | -0.08 | RF |
| Jonathan Van Every | 21 | 5 | 1 | 0.211 | 0.286 | 0.14 | CF |
| Dusty Brown | 12 | 0 | 2 | 0.250 | 0.250 | -0.07 | X |
| Jarrod Saltalamacchia | 12 | 1 | 0 | 0.222 | 0.417 | -0.17 | X |
| Yamaico Navarro | 11 | 0 | 1 | 0.182 | 0.182 | -0.15 | SS |
| Gustavo Molina | 7 | 1 | 0 | 0.143 | 0.143 | -0.06 | X |
| Ryan Shealy | 7 | 0 | 0 | 0.000 | 0.000 | -0.16 | X |
| Niuman Romero | 4 | 0 | 0 | 0.000 | 0.000 | -0.09 | X |
| Angel Sanchez | 3 | 0 | 0 | 0.000 | 0.000 | -0.07 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| John Lackey | 183.0 | 4.48 | 28 | 0 | X | -1.76 |
| Jon Lester | 176.0 | 3.27 | 27 | 0 | X | 3.24 |
| Clay Buchholz | 151.7 | 2.25 | 24 | 0 | X | 6.40 |
| Tim Wakefield | 126.7 | 5.19 | 17 | 11 | X | -3.32 |
| Daisuke Matsuzaka | 123.7 | 4.29 | 20 | 0 | X | -0.67 |
| Josh Beckett | 95.7 | 6.21 | 16 | 0 | X | -4.79 |
| Daniel Bard | 64.3 | 1.82 | 0 | 61 | X | 3.37 |
| Jonathan Papelbon | 57.7 | 2.81 | 0 | 56 | X | 1.69 |
| Scott Atchison | 49.0 | 3.86 | 1 | 32 | X | 0.23 |
| Manny Delcarmen | 44.0 | 4.70 | 0 | 48 | X | -0.66 |
| Ramon S. Ramirez | 42.3 | 4.46 | 0 | 44 | X | -0.40 |
| Hideki Okajima | 34.3 | 5.50 | 0 | 43 | X | -1.16 |
| Felix Doubront | 25.0 | 4.32 | 3 | 9 | X | -0.15 |
| Scott Schoeneweis | 13.7 | 7.90 | 0 | 15 | X | -1.22 |
| Dustin Richardson | 11.0 | 2.45 | 0 | 20 | X | 0.41 |
| Joe Nelson | 8.3 | 9.72 | 0 | 8 | X | -1.10 |
| Robert Manuel | 7.0 | 3.86 | 0 | 5 | X | 0.03 |
| Michael Bowden | 6.0 | 7.50 | 0 | 6 | X | -0.48 |
| Boof Bonser | 2.0 | 18.00 | 0 | 2 | X | -0.65 |
| Fernando Cabrera | 1.3 | 20.25 | 0 | 1 | X | -0.50 |
| Jonathan Van Every | 1.0 | 18.00 | 0 | 1 | X | -0.33 |
| Bill Hall | 1.0 | 0.00 | 0 | 1 | X | 0.09 |
_