| Name | PA | R | RBI | BA | OBP | SLG | POS |
|---|---|---|---|---|---|---|---|
| Asdrubal Cabrera | 667 | 87 | 92 | 0.273 | 0.332 | 0.460 | SS |
| Carlos Santana | 658 | 84 | 79 | 0.239 | 0.351 | 0.457 | CR-1B |
| Michael Brantley | 496 | 63 | 46 | 0.266 | 0.318 | 0.384 | LF-CF |
| Matt LaPorta | 385 | 34 | 53 | 0.247 | 0.299 | 0.412 | 1B |
| Travis Hafner | 368 | 41 | 57 | 0.280 | 0.361 | 0.449 | DH |
| Jack Hannahan | 366 | 38 | 40 | 0.250 | 0.331 | 0.388 | 3B |
| Shin-Soo Choo | 358 | 37 | 36 | 0.259 | 0.344 | 0.390 | RF |
| Orlando Cabrera | 344 | 35 | 38 | 0.244 | 0.277 | 0.321 | 2B |
| Grady Sizemore | 295 | 34 | 32 | 0.224 | 0.285 | 0.422 | CF-DH |
| Lou Marson | 272 | 26 | 19 | 0.230 | 0.300 | 0.296 | CR |
| Kosuke Fukudome | 258 | 26 | 22 | 0.249 | 0.300 | 0.371 | RF-CF |
| Shelley Duncan | 247 | 29 | 47 | 0.260 | 0.324 | 0.484 | LF-DH |
| Ezequiel Carrera | 226 | 27 | 14 | 0.243 | 0.301 | 0.312 | CF |
| Lonnie Chisenhall | 223 | 27 | 22 | 0.255 | 0.284 | 0.415 | 3B |
| Austin Kearns | 174 | 18 | 7 | 0.200 | 0.302 | 0.287 | LF-RF |
| Travis Buck | 160 | 18 | 18 | 0.228 | 0.275 | 0.342 | LF-RF |
| Jason Kipnis | 150 | 24 | 19 | 0.272 | 0.333 | 0.507 | 2B |
| Jason Donald | 143 | 13 | 8 | 0.318 | 0.364 | 0.402 | 2B-SS |
| Jim Thome | 82 | 11 | 10 | 0.296 | 0.390 | 0.479 | DH |
| Cord Phelps | 80 | 10 | 6 | 0.155 | 0.241 | 0.254 | 2B-DH |
| Adam Everett | 67 | 9 | 1 | 0.217 | 0.277 | 0.233 | 3B |
| Luis Valbuena | 44 | 4 | 1 | 0.209 | 0.227 | 0.279 | 2B |
| Trevor Crowe | 32 | 6 | 2 | 0.214 | 0.313 | 0.250 | LF |
| Jerad Head | 25 | 2 | 1 | 0.125 | 0.160 | 0.167 |
| Name | IP | ERA | Gs | Gr | SO | WHIP |
|---|---|---|---|---|---|---|
| Justin Masterson | 216.0 | 3.21 | 33 | 1 | 158 | 1.28 |
| Roberto Hernandez | 188.3 | 5.25 | 32 | 0 | 109 | 1.41 |
| Josh Tomlin | 165.0 | 4.25 | 26 | 0 | 89 | 1.08 |
| Carlos Carrasco | 124.3 | 4.62 | 21 | 0 | 85 | 1.36 |
| Chad Durbin | 68.0 | 5.53 | 0 | 56 | 59 | 1.64 |
| Joe Smith | 67.0 | 2.01 | 0 | 71 | 45 | 1.09 |
| Ubaldo Jimenez | 65.0 | 5.10 | 11 | 0 | 62 | 1.45 |
| Mitch Talbot | 63.3 | 6.64 | 12 | 0 | 36 | 1.85 |
| Rafael Perez | 63.0 | 3.00 | 0 | 71 | 33 | 1.24 |
| Tony Sipp | 62.0 | 3.03 | 0 | 69 | 57 | 1.11 |
| Vinnie Pestano | 62.0 | 2.32 | 0 | 67 | 84 | 1.05 |
| Chris Perez | 59.3 | 3.32 | 0 | 64 | 39 | 1.21 |
| Jeanmar Gomez | 58.0 | 4.47 | 10 | 1 | 31 | 1.51 |
| Frank Herrmann | 56.0 | 5.11 | 0 | 40 | 34 | 1.54 |
| David Huff | 50.3 | 4.09 | 10 | 1 | 36 | 1.42 |
| Zach McAllister | 17.3 | 6.11 | 4 | 0 | 14 | 1.87 |
| Alex White | 15.0 | 3.60 | 3 | 0 | 13 | 1.53 |
| Josh Judy | 14.0 | 7.07 | 0 | 12 | 10 | 1.57 |
| Justin Germano | 12.3 | 5.68 | 0 | 9 | 5 | 1.58 |
| Nick Hagadone | 11.0 | 4.09 | 0 | 9 | 11 | 0.91 |
| Zach Putnam | 7.0 | 6.14 | 0 | 8 | 9 | 1.36 |
| Corey Kluber | 4.0 | 8.31 | 0 | 3 | 5 | 2.08 |
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