| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 334 | 45 | 33 | 0.274 | 0.389 | 0.96 | 2B |
| Adrian Gonzalez | 334 | 55 | 70 | 0.359 | 0.410 | 5.90 | 1B |
| Jacoby Ellsbury | 330 | 53 | 38 | 0.309 | 0.370 | 2.42 | CF |
| David Ortiz | 304 | 49 | 48 | 0.313 | 0.391 | 3.61 | DH |
| Kevin Youkilis | 299 | 45 | 53 | 0.279 | 0.395 | 3.82 | 3B |
| Carl Crawford | 278 | 33 | 31 | 0.242 | 0.273 | 0.71 | LF |
| Jed Lowrie | 216 | 27 | 25 | 0.270 | 0.319 | 0.79 | SS-3B |
| J.D. Drew | 215 | 19 | 18 | 0.228 | 0.330 | -0.77 | RF |
| Jarrod Saltalamacchia | 166 | 19 | 20 | 0.250 | 0.313 | 0.50 | CR |
| Marco Scutaro | 129 | 15 | 13 | 0.293 | 0.357 | 0.15 | SS |
| Jason Varitek | 123 | 16 | 15 | 0.234 | 0.325 | 0.59 | CR |
| Mike Cameron | 98 | 9 | 9 | 0.161 | 0.224 | -0.23 | CF |
| Darnell McDonald | 40 | 3 | 3 | 0.108 | 0.175 | -0.24 | RF-LF-CF |
| Drew Sutton | 39 | 6 | 5 | 0.297 | 0.308 | 0.31 | X |
| Josh Reddick | 26 | 6 | 7 | 0.409 | 0.462 | 0.80 | RF-LF |
| Jose Iglesias | 4 | 0 | 0 | 0.000 | 0.000 | -0.09 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 97.3 | 3.70 | 15 | 0 | X | 0.32 |
| Josh Beckett | 92.0 | 1.86 | 14 | 0 | X | 4.26 |
| Clay Buchholz | 82.7 | 3.48 | 14 | 0 | X | 0.69 |
| Tim Wakefield | 63.3 | 4.26 | 8 | 9 | X | -0.62 |
| John Lackey | 62.3 | 7.36 | 11 | 0 | X | -5.12 |
| Alfredo Aceves | 48.7 | 3.70 | 4 | 15 | X | 0.16 |
| Daisuke Matsuzaka | 37.3 | 5.30 | 7 | 1 | X | -1.27 |
| Daniel Bard | 35.3 | 2.55 | 0 | 33 | X | 1.07 |
| Jonathan Papelbon | 29.0 | 4.03 | 0 | 29 | X | -0.13 |
| Matt Albers | 28.3 | 2.86 | 0 | 23 | X | 0.65 |
| Dan Wheeler | 21.7 | 6.65 | 0 | 22 | X | -1.42 |
| Scott Atchison | 13.3 | 4.72 | 0 | 7 | X | -0.27 |
| Bobby Jenks | 12.3 | 6.57 | 0 | 14 | X | -0.78 |
| Hideki Okajima | 8.3 | 4.32 | 0 | 7 | X | -0.09 |
| Rich Hill | 8.0 | 0.00 | 0 | 9 | X | 0.72 |
| Michael Bowden | 7.0 | 1.29 | 0 | 6 | X | 0.42 |
| Andrew Miller | 5.7 | 4.76 | 1 | 0 | X | -0.12 |
| Tommy Hottovy | 3.7 | 7.36 | 0 | 7 | X | -0.30 |
| Franklin Morales | 3.0 | 6.00 | 0 | 2 | X | -0.15 |
| Felix Doubront | 2.7 | 6.75 | 0 | 3 | X | -0.18 |
| Dennys Reyes | 1.7 | 10.80 | 0 | 4 | X | -0.27 |
_