| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 353 | 46 | 34 | 0.273 | 0.388 | 0.73 | 2B |
| Adrian Gonzalez | 352 | 56 | 72 | 0.357 | 0.412 | 5.79 | 1B |
| Jacoby Ellsbury | 349 | 55 | 39 | 0.297 | 0.358 | 2.29 | CF |
| Kevin Youkilis | 315 | 46 | 55 | 0.272 | 0.394 | 3.76 | 3B |
| David Ortiz | 307 | 50 | 48 | 0.311 | 0.391 | 3.62 | DH |
| Carl Crawford | 278 | 33 | 31 | 0.242 | 0.273 | 0.68 | LF |
| J.D. Drew | 221 | 19 | 18 | 0.232 | 0.330 | -0.92 | RF |
| Jed Lowrie | 216 | 27 | 25 | 0.270 | 0.319 | 0.77 | SS-3B |
| Jarrod Saltalamacchia | 174 | 20 | 20 | 0.258 | 0.322 | 0.42 | CR |
| Marco Scutaro | 144 | 16 | 13 | 0.277 | 0.340 | -0.08 | SS |
| Jason Varitek | 130 | 16 | 15 | 0.239 | 0.323 | 0.43 | CR |
| Mike Cameron | 105 | 9 | 9 | 0.149 | 0.210 | -0.39 | CF |
| Darnell McDonald | 52 | 3 | 3 | 0.122 | 0.173 | -0.50 | RF-LF-CF |
| Drew Sutton | 40 | 6 | 5 | 0.289 | 0.300 | 0.29 | X |
| Josh Reddick | 35 | 7 | 10 | 0.414 | 0.457 | 1.02 | RF-LF |
| Jose Iglesias | 4 | 0 | 0 | 0.000 | 0.000 | -0.09 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 103.3 | 3.66 | 16 | 0 | X | 0.48 |
| Josh Beckett | 98.0 | 2.20 | 15 | 0 | X | 3.78 |
| Clay Buchholz | 82.7 | 3.48 | 14 | 0 | X | 0.72 |
| Tim Wakefield | 69.3 | 4.54 | 9 | 9 | X | -1.11 |
| John Lackey | 62.3 | 7.36 | 11 | 0 | X | -5.10 |
| Alfredo Aceves | 49.7 | 3.62 | 4 | 16 | X | 0.27 |
| Daniel Bard | 37.7 | 2.39 | 0 | 35 | X | 1.29 |
| Daisuke Matsuzaka | 37.3 | 5.30 | 7 | 1 | X | -1.26 |
| Jonathan Papelbon | 30.0 | 3.90 | 0 | 30 | X | -0.03 |
| Matt Albers | 29.7 | 3.03 | 0 | 25 | X | 0.57 |
| Dan Wheeler | 22.7 | 6.35 | 0 | 23 | X | -1.32 |
| Bobby Jenks | 13.3 | 6.07 | 0 | 15 | X | -0.69 |
| Scott Atchison | 13.3 | 4.72 | 0 | 7 | X | -0.27 |
| Andrew Miller | 11.7 | 3.09 | 2 | 0 | X | 0.21 |
| Hideki Okajima | 8.3 | 4.32 | 0 | 7 | X | -0.09 |
| Rich Hill | 8.0 | 0.00 | 0 | 9 | X | 0.72 |
| Michael Bowden | 7.0 | 1.29 | 0 | 6 | X | 0.42 |
| Tommy Hottovy | 4.0 | 6.75 | 0 | 8 | X | -0.27 |
| Franklin Morales | 4.0 | 4.50 | 0 | 3 | X | -0.06 |
| Felix Doubront | 2.7 | 6.75 | 0 | 3 | X | -0.18 |
| Dennys Reyes | 1.7 | 10.80 | 0 | 4 | X | -0.27 |
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