| Name | PA | R | RBI | BA | OBP | SLG | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 623 | 81 | 65 | 0.290 | 0.347 | 0.449 | 2B |
| Mike Aviles | 546 | 57 | 60 | 0.250 | 0.282 | 0.381 | SS |
| Cody Ross | 528 | 70 | 81 | 0.267 | 0.326 | 0.481 | RF-LF-DH |
| Adrian Gonzalez | 527 | 63 | 86 | 0.300 | 0.343 | 0.469 | 1B-RF |
| Jarrod Saltalamacchia | 448 | 55 | 59 | 0.222 | 0.288 | 0.454 | CR-DH |
| David Ortiz | 383 | 65 | 60 | 0.318 | 0.415 | 0.611 | DH |
| Jacoby Ellsbury | 323 | 43 | 26 | 0.271 | 0.313 | 0.370 | CF |
| Daniel Nava | 317 | 38 | 33 | 0.243 | 0.352 | 0.390 | LF |
| Will Middlebrooks | 286 | 34 | 54 | 0.288 | 0.325 | 0.509 | 3B |
| Pedro Ciriaco | 272 | 33 | 19 | 0.293 | 0.315 | 0.390 | 3B-2B-SS-DH |
| Ryan Sweeney | 219 | 22 | 16 | 0.260 | 0.303 | 0.373 | RF-CF |
| Scott Podsednik | 216 | 19 | 12 | 0.302 | 0.322 | 0.352 | LF-CF |
| Ryan Lavarnway | 166 | 11 | 12 | 0.157 | 0.211 | 0.248 | CR-DH |
| Kevin Youkilis | 165 | 25 | 14 | 0.233 | 0.315 | 0.377 | 3B-1B |
| Kelly Shoppach | 158 | 16 | 17 | 0.250 | 0.327 | 0.471 | CR |
| Nick Punto | 148 | 14 | 10 | 0.200 | 0.301 | 0.272 | 3B-2B |
| Carl Crawford | 125 | 23 | 19 | 0.282 | 0.306 | 0.479 | LF |
| Mauro Gomez | 111 | 14 | 17 | 0.275 | 0.324 | 0.422 | 1B |
| Marlon Byrd | 106 | 9 | 7 | 0.270 | 0.286 | 0.320 | CF |
| James Loney | 106 | 5 | 8 | 0.230 | 0.264 | 0.310 | 1B |
| Ryan Kalish | 103 | 12 | 5 | 0.229 | 0.272 | 0.260 | CF |
| Darnell McDonald | 99 | 17 | 9 | 0.214 | 0.309 | 0.369 | LF-RF |
| Jose Iglesias | 77 | 5 | 2 | 0.118 | 0.200 | 0.191 | SS |
| Danny Valencia | 29 | 1 | 4 | 0.143 | 0.138 | 0.250 | 3B |
| Brent Lillibridge | 16 | 0 | 0 | 0.125 | 0.125 | 0.125 | |
| Che-Hsuan Lin | 12 | 1 | 0 | 0.250 | 0.250 | 0.250 | |
| Jason Repko | 11 | 0 | 0 | 0.091 | 0.091 | 0.091 | |
| Lars Anderson | 8 | 1 | 0 | 0.125 | 0.125 | 0.125 | |
| Ivan De Jesus | 8 | 0 | 0 | 0.000 | 0.000 | 0.000 | |
| Nate Spears | 4 | 0 | 0 | 0.000 | 0.000 | 0.000 | |
| Guillermo Quiroz | 2 | 0 | 0 | 0.000 | 0.000 | 0.000 |
| Name | IP | ERA | Gs | Gr | SO | WHIP |
|---|---|---|---|---|---|---|
| Jon Lester | 205.0 | 4.82 | 33 | 0 | 166 | 1.38 |
| Clay Buchholz | 189.0 | 4.56 | 29 | 0 | 129 | 1.33 |
| Felix Doubront | 161.0 | 4.86 | 29 | 0 | 167 | 1.45 |
| Josh Beckett | 127.0 | 5.23 | 21 | 0 | 94 | 1.33 |
| Aaron Cook | 94.0 | 5.65 | 18 | 0 | 20 | 1.47 |
| Alfredo Aceves | 84.0 | 5.36 | 0 | 69 | 75 | 1.32 |
| Franklin Morales | 76.0 | 3.77 | 9 | 28 | 76 | 1.23 |
| Daniel Bard | 59.0 | 6.22 | 10 | 7 | 38 | 1.74 |
| Scott Atchison | 51.0 | 1.58 | 0 | 42 | 36 | 0.99 |
| Vicente Padilla | 50.0 | 4.50 | 0 | 56 | 51 | 1.48 |
| Daisuke Matsuzaka | 45.3 | 8.28 | 11 | 0 | 41 | 1.71 |
| Mark Melancon | 45.0 | 6.20 | 0 | 41 | 41 | 1.27 |
| Junichi Tazawa | 44.0 | 1.43 | 0 | 37 | 45 | 0.95 |
| Clayton Mortensen | 42.0 | 3.21 | 0 | 26 | 41 | 1.21 |
| Andrew Miller | 40.0 | 3.35 | 0 | 53 | 51 | 1.19 |
| Matt Albers | 39.0 | 2.29 | 0 | 40 | 25 | 1.14 |
| Craig Breslow | 20.0 | 2.70 | 0 | 23 | 19 | 1.15 |
| Rich Hill | 19.3 | 1.83 | 0 | 25 | 21 | 1.42 |
| Andrew Bailey | 15.0 | 7.04 | 0 | 19 | 14 | 1.89 |
| Pedro Beato | 7.3 | 4.70 | 0 | 4 | 7 | 1.17 |
| Chris Carpenter | 6.0 | 9.00 | 0 | 8 | 2 | 2.83 |
| Justin Germano | 5.3 | 0.00 | 0 | 1 | 7 | 1.24 |
| Zach Stewart | 5.3 | 22.24 | 2 | 0 | 3 | 3.00 |
| Justin Thomas | 4.3 | 7.71 | 0 | 7 | 4 | 2.57 |
| Michael Bowden | 3.0 | 3.00 | 0 | 2 | 3 | 1.00 |
| Darnell McDonald | 1.0 | 27.00 | 0 | 1 | 0 | 4.00 |
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