| Tm | Name | W | L | Start | End | |
|---|---|---|---|---|---|---|
| BOS | Bill Carrigan | 57 | 96 | Beg | End | |
| BOS | Jack Slattery | 11 | 20 | Beg | 19280522 | |
| BOS | Rogers Hornsby | 39 | 83 | 19280525 | End | |
| CHA | Ray Schalk | 32 | 42 | Beg | 19280704 | |
| CHA | Lena Blackburne | 40 | 40 | 19280706 | End | |
| CHN | Joe McCarthy | 91 | 63 | Beg | End | |
| CIN | Jack Hendricks | 78 | 74 | Beg | End | |
| CLE | Roger Peckinpaugh | 62 | 92 | Beg | End | |
| DET | George Moriarty | 68 | 86 | Beg | End | |
| LAN | Wilbert Robinson | 77 | 76 | Beg | End | |
| NYA | Miller Huggins | 101 | 53 | Beg | End | |
| OAK | Connie Mack | 98 | 55 | Beg | End | |
| PHI | Burt Shotton | 43 | 109 | Beg | End | |
| PIT | Donie Bush | 85 | 67 | Beg | End | |
| SFN | John McGraw | 13 | 10 | Beg | 19280514 | |
| SFN | Roger Bresnahan | 24 | 16 | 19280515 | 19280628 | |
| SFN | John McGraw | 31 | 23 | 19280630 | 19280826 | |
| SFN | Roger Bresnahan | 0 | 3 | 19280828 | 19280829 | |
| SFN | John McGraw | 25 | 9 | 19280831 | End | |
| SLN | Dan Howley | 82 | 72 | Beg | End | |
| SLN | Bill McKechnie | 95 | 59 | Beg | End | |
| TEX | Bucky Harris | 75 | 79 | Beg | End |
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