| Tm | Name | W | L | Start | End | |
|---|---|---|---|---|---|---|
| BOS | Joe McCarthy | 31 | 28 | Beg | 19500618 | |
| BOS | Billy Southworth | 83 | 71 | Beg | End | |
| BOS | Steve O'Neill | 63 | 32 | 19500620 | End | |
| CHA | Jack Onslow | 8 | 22 | Beg | 19500526 | |
| CHA | Red Corriden | 52 | 72 | 19500527 | End | |
| CHN | Frankie Frisch | 64 | 89 | Beg | End | |
| CIN | Luke Sewell | 66 | 87 | Beg | End | |
| CLE | Lou Boudreau | 92 | 62 | Beg | End | |
| DET | Red Rolfe | 95 | 59 | Beg | End | |
| LAN | Burt Shotton | 89 | 65 | Beg | End | |
| NYA | Casey Stengel | 98 | 56 | Beg | End | |
| OAK | Connie Mack | 4 | 5 | Beg | 19500427 | |
| OAK | Earle Mack | 0 | 3 | 19500428 | 19500430 | |
| OAK | Connie Mack | 4 | 6 | 19500504 | 19500514 | |
| OAK | Earle Mack | 1 | 1 | 19500516 | 19500517 | |
| OAK | Connie Mack | 43 | 87 | 19500518 | End | |
| PHI | Eddie Sawyer | 91 | 63 | Beg | End | |
| PIT | Billy Meyer | 57 | 96 | Beg | End | |
| SFN | Leo Durocher | 86 | 68 | Beg | End | |
| SLN | Eddie Dyer | 78 | 75 | Beg | End | |
| SLN | Zack Taylor | 58 | 96 | Beg | End | |
| TEX | Bucky Harris | 67 | 87 | Beg | End |
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