| Tm | Name | W | L | Start | End | |
|---|---|---|---|---|---|---|
| BOS | Steve O'Neill | 54 | 35 | Beg | 19510722 | |
| BOS | Billy Southworth | 28 | 31 | Beg | 19510619 | |
| BOS | Tommy Holmes | 48 | 47 | 19510620 | End | |
| BOS | Earle Combs | 2 | 1 | 19510724 | 19510726 | |
| BOS | Steve O'Neill | 31 | 31 | 19510727 | End | |
| CHA | Paul Richards | 81 | 73 | Beg | End | |
| CHN | Frankie Frisch | 35 | 45 | Beg | 19510721 | |
| CHN | Phil Cavarretta | 27 | 47 | 19510722 | End | |
| CIN | Luke Sewell | 68 | 86 | Beg | End | |
| CLE | Al Lopez | 93 | 61 | Beg | End | |
| DET | Red Rolfe | 73 | 81 | Beg | End | |
| LAN | Chuck Dressen | 97 | 60 | Beg | End | |
| NYA | Casey Stengel | 98 | 56 | Beg | End | |
| OAK | Jimmy Dykes | 70 | 84 | Beg | End | |
| PHI | Eddie Sawyer | 73 | 81 | Beg | End | |
| PIT | Billy Meyer | 7 | 5 | Beg | 19510502 | |
| PIT | Milt Stock | 1 | 0 | 19510503 | 19510503 | |
| PIT | Billy Meyer | 56 | 85 | 19510504 | End | |
| SFN | Leo Durocher | 98 | 59 | Beg | End | |
| SLN | Marty Marion | 6 | 3 | Beg | 19510429 | |
| SLN | Zack Taylor | 52 | 102 | Beg | End | |
| SLN | Ray Blades | 1 | 0 | 19510501 | 19510501 | |
| SLN | Marty Marion | 74 | 70 | 19510502 | End | |
| TEX | Bucky Harris | 62 | 92 | Beg | End |
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