| Tm | Name | W | L | Start | End | |
|---|---|---|---|---|---|---|
| ANA | Mike Scioscia | 75 | 87 | Beg | End | |
| ARI | Bob Brenly | 92 | 70 | Beg | End | |
| ATL | Bobby Cox | 88 | 74 | Beg | End | |
| BAL | Mike Hargrove | 63 | 98 | Beg | End | |
| BOS | Jimy Williams | 65 | 53 | Beg | 20010815 | |
| BOS | Joe Kerrigan | 17 | 26 | 20010816 | End | |
| CHA | Jerry Manuel | 83 | 79 | Beg | End | |
| CHN | Don Baylor | 88 | 74 | Beg | End | |
| CIN | Bob Boone | 66 | 96 | Beg | End | |
| CLE | Charlie Manuel | 27 | 12 | Beg | 20010518 | |
| CLE | Grady Little | 1 | 1 | 20010519 | 20010520 | |
| CLE | Charlie Manuel | 3 | 4 | 20010522 | 20010528 | |
| CLE | Grady Little | 2 | 0 | 20010529 | 20010530 | |
| CLE | Charlie Manuel | 39 | 39 | 20010601 | 20010824 | |
| CLE | Grady Little | 0 | 1 | 20010825 | 20010825 | |
| CLE | Charlie Manuel | 1 | 0 | 20010826 | 20010826 | |
| CLE | Grady Little | 4 | 2 | 20010828 | 20010902 | |
| CLE | Charlie Manuel | 9 | 6 | 20010903 | 20010924 | |
| CLE | Grady Little | 4 | 3 | 20010925 | 20011004 | |
| CLE | Charlie Manuel | 1 | 3 | 20011005 | End | |
| COL | Buddy Bell | 73 | 89 | Beg | End | |
| DET | Phil Garner | 66 | 96 | Beg | End | |
| HOU | Larry Dierker | 93 | 69 | Beg | End | |
| KCA | Tony Muser | 27 | 44 | Beg | 20010620 | |
| KCA | Jamie Quirk | 0 | 1 | 20010622 | 20010622 | |
| KCA | Tony Muser | 38 | 52 | 20010623 | End | |
| LAN | Jim Tracy | 86 | 76 | Beg | End | |
| MIA | John Boles | 22 | 27 | Beg | 20010528 | |
| MIA | Tony Perez | 54 | 59 | 20010529 | End | |
| MIL | Davey Lopes | 68 | 94 | Beg | End | |
| MIN | Tom Kelly | 85 | 77 | Beg | End | |
| NYA | Joe Torre | 95 | 65 | Beg | End | |
| NYN | Bobby Valentine | 82 | 80 | Beg | End | |
| OAK | Art Howe | 102 | 60 | Beg | End | |
| PHI | Larry Bowa | 86 | 76 | Beg | End | |
| PIT | Lloyd McClendon | 62 | 100 | Beg | End | |
| SDN | Bruce Bochy | 79 | 83 | Beg | End | |
| SEA | Lou Piniella | 42 | 12 | Beg | 20010602 | |
| SEA | John McLaren | 4 | 0 | 20010603 | 20010606 | |
| SEA | Lou Piniella | 70 | 34 | 20010608 | End | |
| SFN | Dusty Baker | 90 | 72 | Beg | End | |
| SLN | Tony LaRussa | 93 | 69 | Beg | End | |
| TBA | Larry Rothschild | 4 | 10 | Beg | 20010417 | |
| TBA | Hal McRae | 58 | 90 | 20010418 | End | |
| TEX | Johnny Oates | 11 | 17 | Beg | 20010503 | |
| TEX | Jerry Narron | 62 | 72 | 20010505 | End | |
| TOR | Buck Martinez | 24 | 21 | Beg | 20010523 | |
| TOR | Cookie Rojas | 1 | 2 | 20010524 | 20010526 | |
| TOR | Buck Martinez | 55 | 59 | 20010527 | End | |
| WAS | Felipe Alou | 21 | 32 | Beg | 20010530 | |
| WAS | Jeff Torborg | 47 | 62 | 20010531 | End |
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