| Tm | Name | W | L | Start | End | |
|---|---|---|---|---|---|---|
| ANA | Mike Scioscia | 100 | 62 | Beg | End | |
| ARI | Bob Melvin | 82 | 80 | Beg | End | |
| ATL | Bobby Cox | 47 | 52 | Beg | 20080721 | |
| ATL | Chino Cadahia | 0 | 1 | 20080722 | 20080722 | |
| ATL | Bobby Cox | 25 | 37 | 20080723 | End | |
| BAL | Dave Trembley | 68 | 93 | Beg | End | |
| BOS | Terry Francona | 24 | 17 | Beg | 20080512 | |
| BOS | Brad Mills | 0 | 2 | 20080513 | 20080514 | |
| BOS | Terry Francona | 71 | 48 | 20080517 | End | |
| CHA | Ozzie Guillen | 61 | 50 | Beg | 20080803 | |
| CHA | Joey Cora | 2 | 0 | 20080805 | 20080806 | |
| CHA | Ozzie Guillen | 26 | 24 | 20080807 | End | |
| CHN | Lou Piniella | 97 | 64 | Beg | End | |
| CIN | Dusty Baker | 21 | 27 | Beg | 20080522 | |
| CIN | Chris Speier | 2 | 0 | 20080523 | 20080524 | |
| CIN | Dusty Baker | 51 | 61 | 20080525 | End | |
| CLE | Eric Wedge | 81 | 81 | Beg | End | |
| COL | Clint Hurdle | 74 | 88 | Beg | End | |
| DET | Jim Leyland | 71 | 80 | Beg | 20080917 | |
| DET | Lloyd McClendon | 0 | 3 | 20080919 | 20080921 | |
| DET | Jim Leyland | 3 | 5 | 20080922 | End | |
| HOU | Cecil Cooper | 86 | 75 | Beg | End | |
| KCA | Trey Hillman | 75 | 87 | Beg | End | |
| LAN | Joe Torre | 84 | 78 | Beg | End | |
| MIA | Fredi Gonzalez | 84 | 77 | Beg | End | |
| MIL | Ned Yost | 83 | 67 | Beg | 20080914 | |
| MIL | Dale Sveum | 7 | 5 | 20080916 | End | |
| MIN | Ron Gardenhire | 13 | 14 | Beg | 20080430 | |
| MIN | Scott Ullger | 4 | 1 | 20080502 | 20080507 | |
| MIN | Ron Gardenhire | 11 | 10 | 20080508 | 20080529 | |
| MIN | Scott Ullger | 0 | 1 | 20080530 | 20080530 | |
| MIN | Ron Gardenhire | 31 | 22 | 20080531 | 20080730 | |
| MIN | Scott Ullger | 1 | 0 | 20080731 | 20080731 | |
| MIN | Ron Gardenhire | 28 | 27 | 20080801 | End | |
| NYA | Joe Girardi | 2 | 1 | Beg | 20080403 | |
| NYA | Rob Thomson | 0 | 2 | 20080404 | 20080405 | |
| NYA | Joe Girardi | 20 | 22 | 20080406 | 20080522 | |
| NYA | Rob Thomson | 1 | 0 | 20080523 | 20080523 | |
| NYA | Joe Girardi | 66 | 48 | 20080524 | End | |
| NYN | Willie Randolph | 34 | 35 | Beg | 20080616 | |
| NYN | Jerry Manuel | 55 | 38 | 20080617 | End | |
| OAK | Bob Geren | 75 | 86 | Beg | End | |
| PHI | Charlie Manuel | 92 | 70 | Beg | End | |
| PIT | John Russell | 67 | 95 | Beg | End | |
| SDN | Buddy Black | 63 | 99 | Beg | End | |
| SEA | John McLaren | 25 | 47 | Beg | 20080618 | |
| SEA | Jim Riggleman | 36 | 54 | 20080620 | End | |
| SFN | Bruce Bochy | 72 | 90 | Beg | End | |
| SLN | Tony LaRussa | 86 | 76 | Beg | End | |
| TBA | Joe Maddon | 97 | 65 | Beg | End | |
| TEX | Ron Washington | 79 | 83 | Beg | End | |
| TOR | John Gibbons | 35 | 39 | Beg | 20080619 | |
| TOR | Cito Gaston | 51 | 37 | 20080620 | End | |
| WAS | Manny Acta | 59 | 102 | Beg | End |
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