| Tm | Name | W | L | Start | End | |
|---|---|---|---|---|---|---|
| ANA | Mike Scioscia | 80 | 82 | Beg | End | |
| ARI | A.J. Hinch | 31 | 48 | Beg | 20100630 | |
| ARI | Kirk Gibson | 34 | 49 | 20100702 | End | |
| ATL | Bobby Cox | 54 | 38 | Beg | 20100718 | |
| ATL | Chino Cadahia | 1 | 0 | 20100720 | 20100720 | |
| ATL | Bobby Cox | 36 | 33 | 20100721 | End | |
| BAL | Dave Trembley | 15 | 39 | Beg | 20100603 | |
| BAL | Juan Samuel | 17 | 34 | 20100604 | 20100801 | |
| BAL | Buck Showalter | 34 | 23 | 20100803 | End | |
| BOS | Terry Francona | 89 | 73 | Beg | End | |
| CHA | Ozzie Guillen | 88 | 74 | Beg | End | |
| CHN | Lou Piniella | 47 | 64 | Beg | 20100808 | |
| CHN | Alan Trammell | 1 | 3 | 20100809 | 20100812 | |
| CHN | Lou Piniella | 3 | 7 | 20100813 | 20100822 | |
| CHN | Mike Quade | 24 | 13 | 20100823 | End | |
| CIN | Dusty Baker | 64 | 51 | Beg | 20100811 | |
| CIN | Chris Speier | 2 | 0 | 20100813 | 20100814 | |
| CIN | Dusty Baker | 25 | 20 | 20100815 | End | |
| CLE | Manny Acta | 69 | 93 | Beg | End | |
| COL | Jim Tracy | 83 | 79 | Beg | End | |
| DET | Jim Leyland | 51 | 48 | Beg | 20100727 | |
| DET | Lloyd McClendon | 0 | 1 | 20100728 | 20100728 | |
| DET | Jim Leyland | 30 | 32 | 20100729 | End | |
| HOU | Brad Mills | 76 | 86 | Beg | End | |
| KCA | Trey Hillman | 12 | 23 | Beg | 20100513 | |
| KCA | Ned Yost | 55 | 72 | 20100514 | End | |
| LAN | Joe Torre | 49 | 45 | Beg | 20100720 | |
| LAN | Don Mattingly | 1 | 0 | 20100721 | 20100721 | |
| LAN | Joe Torre | 30 | 37 | 20100722 | End | |
| MIA | Fredi Gonzalez | 34 | 36 | Beg | 20100622 | |
| MIA | Edwin Rodriguez | 46 | 46 | 20100623 | End | |
| MIL | Ken Macha | 77 | 85 | Beg | End | |
| MIN | Ron Gardenhire | 94 | 68 | Beg | End | |
| NYA | Joe Girardi | 95 | 67 | Beg | End | |
| NYN | Jerry Manuel | 79 | 83 | Beg | End | |
| OAK | Bob Geren | 81 | 81 | Beg | End | |
| PHI | Charlie Manuel | 18 | 11 | Beg | 20100507 | |
| PHI | Pete Mackanin | 0 | 1 | 20100508 | 20100508 | |
| PHI | Charlie Manuel | 79 | 53 | 20100509 | End | |
| PIT | John Russell | 57 | 105 | Beg | End | |
| SDN | Buddy Black | 36 | 25 | Beg | 20100611 | |
| SDN | Ted Simmons | 1 | 0 | 20100612 | 20100612 | |
| SDN | Buddy Black | 53 | 47 | 20100613 | End | |
| SEA | Don Wakamatsu | 42 | 70 | Beg | 20100808 | |
| SEA | Daren Brown | 19 | 31 | 20100809 | End | |
| SFN | Bruce Bochy | 92 | 70 | Beg | End | |
| SLN | Tony LaRussa | 64 | 49 | Beg | 20100811 | |
| SLN | Joe Pettini | 1 | 1 | 20100813 | 20100814 | |
| SLN | Tony LaRussa | 21 | 26 | 20100815 | End | |
| TBA | Joe Maddon | 96 | 66 | Beg | End | |
| TEX | Ron Washington | 90 | 72 | Beg | End | |
| TOR | Cito Gaston | 85 | 77 | Beg | End | |
| WAS | Jim Riggleman | 69 | 93 | Beg | End |
_