| Tm | Name | W | L | Start | End | |
|---|---|---|---|---|---|---|
| ANA | Joe Maddon | 27 | 29 | Beg | 20220606 | |
| ANA | Phil Nevin | 46 | 60 | 20220607 | End | |
| ARI | Torey Lovullo | 74 | 88 | Beg | End | |
| ATL | Brian Snitker | 101 | 61 | Beg | End | |
| BAL | Brandon Hyde | 83 | 79 | Beg | End | |
| BOS | Alex Cora | 78 | 84 | Beg | End | |
| CHA | Tony LaRussa | 63 | 66 | Beg | 20220830 | |
| CHA | Miguel Cairo | 18 | 15 | 20220831 | End | |
| CHN | David Ross | 74 | 88 | Beg | End | |
| CIN | David Bell | 62 | 100 | Beg | End | |
| CLE | Terry Francona | 92 | 70 | Beg | End | |
| COL | Buddy Black | 68 | 94 | Beg | End | |
| DET | A.J. Hinch | 66 | 96 | Beg | End | |
| HOU | Dusty Baker | 106 | 56 | Beg | End | |
| KCA | Mike Matheny | 65 | 97 | Beg | End | |
| LAN | Dave Roberts | 111 | 51 | Beg | End | |
| MIA | Don Mattingly | 69 | 93 | Beg | End | |
| MIL | Craig Counsell | 86 | 76 | Beg | End | |
| MIN | Rocco Baldelli | 78 | 84 | Beg | End | |
| NYA | Aaron Boone | 99 | 63 | Beg | End | |
| NYN | Buck Showalter | 101 | 61 | Beg | End | |
| OAK | Mark Kotsay | 60 | 102 | Beg | End | |
| PHI | Joe Girardi | 22 | 29 | Beg | 20220601 | |
| PHI | Rob Thomson | 65 | 46 | 20220603 | End | |
| PIT | Derek Shelton | 62 | 100 | Beg | End | |
| SDN | Bob Melvin | 89 | 73 | Beg | End | |
| SEA | Scott Servais | 90 | 72 | Beg | End | |
| SFN | Gabe Kapler | 81 | 81 | Beg | End | |
| SLN | Oliver Marmol | 93 | 69 | Beg | End | |
| TBA | Kevin Cash | 86 | 76 | Beg | End | |
| TEX | Chris Woodward | 51 | 63 | Beg | 20220814 | |
| TEX | Tony Beasley | 17 | 31 | 20220815 | End | |
| TOR | Charlie Montoyo | 46 | 42 | Beg | 20220712 | |
| TOR | John Schneider | 46 | 28 | 20220713 | End | |
| WAS | Dave Martinez | 55 | 107 | Beg | End |
_