| Starter | Tm | Tier | Game |
|---|---|---|---|
| Carl Mays | NYA | 6.72 | 192107180_NYA_DET |
| Red Faber | CHA | 5.98 | 192107170_BOS_CHA |
| Jesse Barnes | SFN | 4.99 | 192107170_PIT_SFN |
| Babe Adams | PIT | 2.3 | 192107190_PIT_SFN |
| George Mogridge | MIN | 1.01 | 192107180_MIN_CLE |
| Starter | Tm | Tier | Game |
|---|---|---|---|
| Shovel Hodge | CHA | -6.19 | 192107182_BOS_CHA |
| Stan Baumgartner | PHI | -2.31 | 192107182_CIN_PHI |
| Ray Caldwell | CLE | -1.9 | 192107170_MIN_CLE |
| Eric Erickson | MIN | -0.94 | 192107190_MIN_CLE |
| Howard Ehmke | DET | -0.87 | 192107180_NYA_DET |
Based on accumulated WAA for this season up to 1921-07-19.
| Rank | WAA | Name | IP | Tm |
|---|---|---|---|---|
| +002+ | 8.67 | Red Faber | 209.7 | CHA |
| +005+ | 7.29 | Eppa Rixey | 162 | CIN |
| +006+ | 6.6 | Carl Mays | 190 | NYA |
| +009+ | 5.79 | George Mogridge | 168.7 | MIN |
| +013+ | 4.61 | Jesse Barnes | 143.7 | SFN |
| +019+ | 3.44 | Burleigh Grimes | 144 | LAN |
| +021+ | 3.32 | Sad Sam Jones | 175 | BOS |
| +024+ | 3.25 | Herb Pennock | 126.7 | BOS |
| +025+ | 3.24 | Bill Doak | 104.3 | SLN |
| +027+ | 2.92 | Stan Coveleski | 188.7 | CLE |
| +028+ | 2.72 | Babe Adams | 102.3 | PIT |
| +029+ | 2.71 | Hugh McQuillan | 154 | ATL |
| +032+ | 2.56 | Bullet Joe Bush | 121.7 | BOS |
| +033+ | 2.51 | Pete Alexander | 111 | CHN |
| +034+ | 2.43 | Wilbur Cooper | 172 | PIT |
| +035+ | 2.42 | Dana Fillingim | 126.3 | ATL |
| +037+ | 2.35 | Waite Hoyt | 151.7 | NYA |
| +039+ | 2.34 | Joe Oeschger | 159 | ATL |
| +043+ | 2.23 | Elmer Ponder | 48.7 | TOT |
| +056+ | 1.78 | Allen Russell | 113.7 | BOS |
| +058+ | 1.73 | Bob Shawkey | 120.7 | NYA |
| +060+ | 1.71 | Fred Toney | 128.7 | SFN |
| +062+ | 1.66 | Earl Hamilton | 136.3 | PIT |
| +070+ | 1.42 | Slim Harriss | 154.7 | OAK |
| +076+ | 1.35 | Rosy Ryan | 102.7 | SFN |
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