| Starter | Tm | Tier | Game |
|---|---|---|---|
| Red Faber | CHA | 9.52 | 192107302_CHA_OAK |
| Eppa Rixey | CIN | 6.91 | 192107311_SFN_CIN |
| Carl Mays | NYA | 4.85 | 192107310_CLE_NYA |
| Pete Alexander | CHN | 4.36 | 192107301_PHI_CHN |
| Jesse Barnes | SFN | 3.77 | 192107302_SFN_CIN |
| Starter | Tm | Tier | Game |
|---|---|---|---|
| Roy Wilkinson | CHA | -3.34 | 192108010_CHA_OAK |
| George Smith | PHI | -0.8 | 192108010_PHI_CHN |
| Bob Hasty | OAK | -0.74 | 192107302_CHA_OAK |
| Buck Freeman | CHN | -0.73 | 192107302_PHI_CHN |
| Jim Bagby | CLE | -0.7 | 192108010_CLE_NYA |
Based on accumulated WAA for this season up to 1921-08-01.
| Rank | WAA | Name | IP | Tm |
|---|---|---|---|---|
| +002+ | 10.58 | Red Faber | 240.7 | CHA |
| +003+ | 9.74 | Eppa Rixey | 200 | CIN |
| +008+ | 6.07 | George Mogridge | 192.3 | MIN |
| +012+ | 5.48 | Carl Mays | 212 | NYA |
| +013+ | 5.25 | Jesse Barnes | 162.3 | SFN |
| +017+ | 4.36 | Wilbur Cooper | 208 | PIT |
| +019+ | 3.9 | Pete Alexander | 148 | CHN |
| +020+ | 3.9 | Burleigh Grimes | 174 | LAN |
| +021+ | 3.83 | Sad Sam Jones | 193 | BOS |
| +023+ | 3.72 | Waite Hoyt | 177.7 | NYA |
| +024+ | 3.52 | Bill Doak | 125.7 | SLN |
| +025+ | 3.46 | Babe Adams | 120.3 | PIT |
| +027+ | 3.4 | Whitey Glazner | 154 | PIT |
| +029+ | 3.31 | Joe Oeschger | 184 | ATL |
| +031+ | 3.23 | Stan Coveleski | 214.7 | CLE |
| +032+ | 3.15 | Bullet Joe Bush | 148.7 | BOS |
| +034+ | 2.78 | Dana Fillingim | 149 | ATL |
| +035+ | 2.77 | Hugh McQuillan | 173.7 | ATL |
| +036+ | 2.67 | Dolf Luque | 192 | CIN |
| +040+ | 2.33 | Guy Morton | 53.7 | CLE |
| +050+ | 1.98 | Jack Scott | 142.7 | ATL |
| +058+ | 1.78 | Herb Pennock | 141 | BOS |
| +061+ | 1.65 | Bill Pertica | 137 | SLN |
| +065+ | 1.6 | Earl Hamilton | 152.7 | PIT |
| +070+ | 1.52 | Rube Marquard | 164.7 | CIN |
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