| Starter | Tm | Tier | Game |
|---|---|---|---|
| Red Faber | CHA | 11.77 | 192108070_CHA_NYA |
| Eppa Rixey | CIN | 6.79 | 192108070_PHI_CIN |
| Carl Mays | NYA | 5.51 | 192108090_CHA_NYA |
| Jesse Barnes | SFN | 3.55 | 192108070_SFN_CHN |
| Wilbur Cooper | PIT | 2.82 | 192108080_LAN_PIT |
| Starter | Tm | Tier | Game |
|---|---|---|---|
| Roy Wilkinson | CHA | -3.89 | 192108090_CHA_NYA |
| Ray Caldwell | CLE | -3.2 | 192108090_CLE_OAK |
| Dixie Davis | BAL | -2.37 | 192108090_BAL_MIN |
| Harry Courtney | MIN | -1.9 | 192108070_BAL_MIN |
| Bob Hasty | OAK | -1.36 | 192108070_OAK_CLE |
Based on accumulated WAA for this season up to 1921-08-09.
| Rank | WAA | Name | IP | Tm |
|---|---|---|---|---|
| +002+ | 11.14 | Red Faber | 256.3 | CHA |
| +003+ | 9.44 | Eppa Rixey | 211 | CIN |
| +009+ | 6.48 | George Mogridge | 210.7 | MIN |
| +011+ | 5.73 | Carl Mays | 230 | NYA |
| +013+ | 5.5 | Jesse Barnes | 178.3 | SFN |
| +014+ | 4.95 | Burleigh Grimes | 192 | LAN |
| +016+ | 4.74 | Bill Doak | 143.7 | SLN |
| +020+ | 4.09 | Babe Adams | 127.3 | PIT |
| +021+ | 4.08 | Wilbur Cooper | 226 | PIT |
| +022+ | 4.03 | Sad Sam Jones | 207 | BOS |
| +023+ | 3.99 | Whitey Glazner | 163 | PIT |
| +027+ | 3.5 | Stan Coveleski | 231.7 | CLE |
| +028+ | 3.46 | Waite Hoyt | 190.3 | NYA |
| +029+ | 3.35 | Bullet Joe Bush | 164.7 | BOS |
| +030+ | 3.22 | Pete Alexander | 166 | CHN |
| +031+ | 3.14 | Hugh McQuillan | 186.7 | ATL |
| +033+ | 3.05 | Dolf Luque | 210 | CIN |
| +035+ | 2.76 | Joe Oeschger | 205 | ATL |
| +042+ | 2.4 | Earl Hamilton | 161.7 | PIT |
| +048+ | 2.15 | Dana Fillingim | 158 | ATL |
| +049+ | 2.12 | Rube Marquard | 182.7 | CIN |
| +052+ | 2.09 | Bill Pertica | 149 | SLN |
| +059+ | 1.77 | Guy Morton | 61.3 | CLE |
| +063+ | 1.62 | Art Nehf | 168.3 | SFN |
| +077+ | 1.28 | Bob Shawkey | 158.3 | NYA |
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