| Starter | Tm | Tier | Game |
|---|---|---|---|
| Eppa Rixey | CIN | 6.38 | 192108110_CIN_SLN |
| Carl Mays | NYA | 5.51 | 192108090_CHA_NYA |
| Jesse Barnes | SFN | 3.64 | 192108112_LAN_SFN |
| Bill Doak | SLN | 2.32 | 192108110_CIN_SLN |
| Babe Adams | PIT | 2.31 | 192108090_LAN_PIT |
| Starter | Tm | Tier | Game |
|---|---|---|---|
| Shovel Hodge | CHA | -7.87 | 192108100_CHA_NYA |
| Ray Caldwell | CLE | -3.2 | 192108090_CLE_OAK |
| Dixie Davis | BAL | -2.37 | 192108090_BAL_MIN |
| Bob Hasty | OAK | -1.13 | 192108110_NYA_OAK |
| Carl Holling | DET | -1.11 | 192108092_DET_BOS |
Based on accumulated WAA for this season up to 1921-08-11.
| Rank | WAA | Name | IP | Tm |
|---|---|---|---|---|
| +002+ | 11.17 | Red Faber | 256.3 | CHA |
| +003+ | 10.11 | Eppa Rixey | 220 | CIN |
| +009+ | 6.49 | George Mogridge | 210.7 | MIN |
| +010+ | 5.74 | Carl Mays | 230 | NYA |
| +013+ | 5.37 | Jesse Barnes | 184.3 | SFN |
| +015+ | 4.9 | Burleigh Grimes | 192 | LAN |
| +019+ | 4.51 | Bill Doak | 145.7 | SLN |
| +020+ | 4.08 | Babe Adams | 127.3 | PIT |
| +021+ | 4.07 | Whitey Glazner | 164 | PIT |
| +022+ | 4.06 | Wilbur Cooper | 226 | PIT |
| +023+ | 4.04 | Sad Sam Jones | 207 | BOS |
| +025+ | 3.86 | Hugh McQuillan | 196.7 | ATL |
| +026+ | 3.53 | Stan Coveleski | 231.7 | CLE |
| +028+ | 3.47 | Waite Hoyt | 190.3 | NYA |
| +030+ | 3.35 | Bullet Joe Bush | 164.7 | BOS |
| +033+ | 2.74 | Joe Oeschger | 205 | ATL |
| +037+ | 2.58 | Earl Hamilton | 170.7 | PIT |
| +038+ | 2.57 | Dolf Luque | 218 | CIN |
| +040+ | 2.5 | Pete Alexander | 174 | CHN |
| +049+ | 2.14 | Dana Fillingim | 158 | ATL |
| +050+ | 2.13 | Rube Marquard | 182.7 | CIN |
| +051+ | 2.09 | Bill Pertica | 149 | SLN |
| +061+ | 1.78 | Guy Morton | 61.3 | CLE |
| +064+ | 1.56 | Art Nehf | 168.3 | SFN |
| +069+ | 1.51 | Bob Shawkey | 167.3 | NYA |
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