| Starter | Tm | Tier | Game |
|---|---|---|---|
| Carl Mays | NYA | 6.45 | 192109151_BAL_NYA |
| Burleigh Grimes | LAN | 4.31 | 192109150_LAN_SLN |
| George Mogridge | MIN | 3.6 | 192109170_CLE_MIN |
| Sad Sam Jones | BOS | 3.47 | 192109170_CHA_BOS |
| Jesse Barnes | SFN | 3.43 | 192109150_SFN_CIN |
| Starter | Tm | Tier | Game |
|---|---|---|---|
| Roy Wilkinson | CHA | -3.6 | 192109160_CHA_BOS |
| Ray Caldwell | CLE | -2.92 | 192109152_CLE_OAK |
| Howard Ehmke | DET | -1.43 | 192109160_DET_OAK |
| Bill Bayne | BAL | -0.79 | 192109151_BAL_NYA |
| Slim Harriss | OAK | -0.57 | 192109170_DET_OAK |
Based on accumulated WAA for this season up to 1921-09-17.
| Rank | WAA | Name | IP | Tm |
|---|---|---|---|---|
| +007+ | 9.09 | Eppa Rixey | 278.7 | CIN |
| +010+ | 8.01 | Carl Mays | 309.3 | NYA |
| +012+ | 7.42 | Burleigh Grimes | 269.3 | LAN |
| +014+ | 6.66 | Jesse Barnes | 249.3 | SFN |
| +016+ | 6.57 | Bill Doak | 193 | SLN |
| +018+ | 6.16 | George Mogridge | 270.7 | MIN |
| +019+ | 6.02 | Sad Sam Jones | 282.7 | BOS |
| +020+ | 6.01 | Waite Hoyt | 253 | NYA |
| +023+ | 5.26 | Stan Coveleski | 288 | CLE |
| +024+ | 5.13 | Whitey Glazner | 219.3 | PIT |
| +027+ | 4.52 | Wilbur Cooper | 300 | PIT |
| +028+ | 4.33 | Dolf Luque | 286 | CIN |
| +029+ | 4.32 | Bill Pertica | 198 | SLN |
| +030+ | 4.26 | Pete Alexander | 227.3 | CHN |
| +031+ | 4.25 | Dana Fillingim | 223.3 | ATL |
| +038+ | 3.84 | Joe Oeschger | 279.7 | ATL |
| +040+ | 3.73 | Rube Marquard | 246.7 | CIN |
| +044+ | 3.42 | Bullet Joe Bush | 220.3 | BOS |
| +046+ | 3.3 | Clarence Mitchell | 165 | LAN |
| +047+ | 3.26 | Johnny Morrison | 123 | PIT |
| +048+ | 2.98 | Benn Karr | 88.3 | BOS |
| +050+ | 2.94 | Fred Toney | 243.3 | SFN |
| +051+ | 2.89 | Jesse Haines | 218.3 | SLN |
| +064+ | 2.15 | Urban Shocker | 300.7 | BAL |
| +066+ | 2.06 | Walter Johnson | 229 | MIN |
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