| Starter | Tm | Tier | Game |
|---|---|---|---|
| Red Faber | CHA | 10.31 | 192109211_CHA_MIN |
| Burleigh Grimes | LAN | 5.26 | 192109221_LAN_PIT |
| Sad Sam Jones | BOS | 3.3 | 192109210_CLE_BOS |
| George Mogridge | MIN | 2.34 | 192109230_DET_MIN |
| Waite Hoyt | NYA | 2.22 | 192109230_CLE_NYA |
| Starter | Tm | Tier | Game |
|---|---|---|---|
| Dixie Davis | BAL | -3.66 | 192109221_BAL_OAK |
| Roy Wilkinson | CHA | -3.59 | 192109231_CHA_OAK |
| Ray Caldwell | CLE | -2.36 | 192109210_CLE_BOS |
| Rollie Naylor | OAK | -2.07 | 192109222_BAL_OAK |
| Howard Ehmke | DET | -1.08 | 192109220_DET_NYA |
Based on accumulated WAA for this season up to 1921-09-23.
| Rank | WAA | Name | IP | Tm |
|---|---|---|---|---|
| +002+ | 11.27 | Red Faber | 312.7 | CHA |
| +008+ | 8.97 | Burleigh Grimes | 285.3 | LAN |
| +010+ | 8.32 | Eppa Rixey | 284.7 | CIN |
| +012+ | 7.79 | Carl Mays | 316.7 | NYA |
| +015+ | 6.75 | George Mogridge | 279.7 | MIN |
| +016+ | 6.53 | Bill Doak | 193 | SLN |
| +018+ | 6.25 | Waite Hoyt | 271.7 | NYA |
| +019+ | 5.83 | Sad Sam Jones | 288.7 | BOS |
| +020+ | 5.81 | Jesse Barnes | 254 | SFN |
| +022+ | 5.66 | Whitey Glazner | 227.3 | PIT |
| +024+ | 5.15 | Wilbur Cooper | 309 | PIT |
| +025+ | 5.04 | Stan Coveleski | 304 | CLE |
| +028+ | 4.54 | Babe Adams | 153 | PIT |
| +030+ | 4.47 | Dolf Luque | 295 | CIN |
| +036+ | 3.99 | Clarence Mitchell | 172 | LAN |
| +037+ | 3.93 | Bill Pertica | 201 | SLN |
| +039+ | 3.68 | Rube Marquard | 255.7 | CIN |
| +041+ | 3.59 | Pete Alexander | 234.3 | CHN |
| +043+ | 3.49 | Johnny Morrison | 130 | PIT |
| +044+ | 3.4 | Dana Fillingim | 227.3 | ATL |
| +045+ | 3.2 | Fred Toney | 246.3 | SFN |
| +046+ | 3.13 | Joe Oeschger | 287.3 | ATL |
| +048+ | 3.07 | Jesse Haines | 227.3 | SLN |
| +049+ | 2.9 | Urban Shocker | 317.7 | BAL |
| +050+ | 2.85 | Bullet Joe Bush | 235.3 | BOS |
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