Based on accumulated WAA for this season up to 1959-07-20.
| Rank | WAA | Name | IP | Tm |
|---|---|---|---|---|
| +002+ | 6.84 | Hoyt Wilhelm | 141.3 | BAL |
| +004+ | 5.99 | Johnny Antonelli | 178.7 | SFN |
| +008+ | 5.41 | Camilo Pascual | 157 | MIN |
| +010+ | 4.68 | Gene Conley | 131.7 | PHI |
| +013+ | 4.29 | Don Drysdale | 180.3 | LAN |
| +015+ | 3.92 | Warren Spahn | 167.7 | ATL |
| +020+ | 3.47 | Harvey Haddix | 142.7 | PIT |
| +027+ | 3.25 | Sam Jones | 160.3 | SFN |
| +028+ | 3.06 | Stu Miller | 117.3 | SFN |
| +030+ | 3.02 | Whitey Ford | 136 | NYA |
| +032+ | 2.99 | Jerry Walker | 100 | BAL |
| +038+ | 2.82 | Bob Rush | 67 | ATL |
| +039+ | 2.77 | Cal McLish | 135 | CLE |
| +040+ | 2.7 | Bob Buhl | 93 | ATL |
| +042+ | 2.64 | Don Newcombe | 130.3 | CIN |
| +048+ | 2.48 | Don Mossi | 121.7 | DET |
| +050+ | 2.44 | Glen Hobbie | 139.7 | CHN |
| +053+ | 2.3 | Frank Lary | 139.7 | DET |
| +054+ | 2.27 | Dave Hillman | 122 | CHN |
| +055+ | 2.26 | Bob Shaw | 118.7 | CHA |
| +061+ | 2.08 | Roger Craig | 52 | LAN |
| +062+ | 2.03 | Bud Daley | 110.7 | OAK |
| +063+ | 1.97 | Tom Brewer | 122 | BOS |
| +066+ | 1.8 | Larry Jackson | 147.7 | SLN |
| +067+ | 1.78 | Ned Garver | 130.3 | OAK |
_