| Starter | Tm | Tier | Game |
|---|---|---|---|
| Bob Shaw | SFN | 3.71 | 196509190_SFN_ATL |
| Mel Stottlemyre | NYA | 3.58 | 196509210_CLE_NYA |
| Jim Maloney | CIN | 3.38 | 196509200_SFN_CIN |
| Sonny Siebert | CLE | 3.21 | 196509190_CHA_CLE |
| Milt Pappas | BAL | 2.78 | 196509210_BAL_MIN |
| Starter | Tm | Tier | Game |
|---|---|---|---|
| Ray Sadecki | SLN | -6.31 | 196509210_HOU_SLN |
| Jim O'Toole | CIN | -5.52 | 196509210_SFN_CIN |
| Bob Hendley | CHN | -1.64 | 196509190_NYN_CHN |
| Al Jackson | NYN | -1.37 | 196509210_NYN_PIT |
| Denny Lemaster | ATL | -1.07 | 196509210_LAN_ATL |
Based on accumulated WAA for this season up to 1965-09-21.
| Rank | WAA | Name | IP | Tm |
|---|---|---|---|---|
| +001+ | 10.3 | Sandy Koufax | 306.7 | LAN |
| +002+ | 10.27 | Juan Marichal | 276.3 | SFN |
| +007+ | 7.83 | Sam McDowell | 245 | CLE |
| +010+ | 6.77 | Vern Law | 217.3 | PIT |
| +013+ | 6.02 | Mel Stottlemyre | 275 | NYA |
| +017+ | 5.5 | Jim Maloney | 240.3 | CIN |
| +021+ | 5.25 | Bob Shaw | 225.3 | SFN |
| +023+ | 5.21 | Jim Bunning | 264 | PHI |
| +036+ | 4.52 | Milt Pappas | 208 | BAL |
| +040+ | 4.23 | Claude Osteen | 265.7 | LAN |
| +041+ | 4.13 | Pete Richert | 172 | TEX |
| +043+ | 4.01 | Sonny Siebert | 165.7 | CLE |
| +045+ | 3.97 | Bob Veale | 252.7 | PIT |
| +049+ | 3.72 | Don Drysdale | 290.3 | LAN |
| +052+ | 3.63 | Jim Kaat | 242.7 | MIN |
| +053+ | 3.62 | Jim Perry | 161 | MIN |
| +056+ | 3.56 | Bobby Bolin | 151 | SFN |
| +059+ | 3.48 | Chris Short | 263.3 | PHI |
| +060+ | 3.46 | Denny McLain | 202.3 | DET |
| +062+ | 3.38 | George Brunet | 177 | ANA |
| +063+ | 3.26 | Bob Gibson | 274.7 | SLN |
| +066+ | 3.21 | Marcelino Lopez | 215.3 | ANA |
| +074+ | 3.02 | Steve Barber | 194.7 | BAL |
| +077+ | 2.89 | Fred Newman | 244.3 | ANA |
| +078+ | 2.89 | Al McBean | 110.3 | PIT |
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