| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 454 | 67 | 50 | 0.299 | 0.401 | 2.43 | 2B |
| Adrian Gonzalez | 448 | 70 | 83 | 0.346 | 0.408 | 6.34 | 1B |
| Jacoby Ellsbury | 447 | 74 | 58 | 0.318 | 0.374 | 4.16 | CF |
| Kevin Youkilis | 400 | 57 | 73 | 0.282 | 0.398 | 4.97 | 3B |
| David Ortiz | 375 | 57 | 59 | 0.296 | 0.381 | 4.04 | DH |
| Carl Crawford | 304 | 37 | 35 | 0.253 | 0.286 | 0.96 | LF |
| J.D. Drew | 271 | 23 | 21 | 0.219 | 0.317 | -1.26 | RF |
| Jarrod Saltalamacchia | 227 | 29 | 31 | 0.259 | 0.326 | 1.37 | CR |
| Marco Scutaro | 226 | 27 | 17 | 0.260 | 0.327 | -0.28 | SS |
| Jed Lowrie | 216 | 27 | 25 | 0.270 | 0.319 | 0.77 | SS-3B |
| Jason Varitek | 164 | 21 | 19 | 0.236 | 0.311 | 0.64 | CR |
| Josh Reddick | 108 | 21 | 20 | 0.358 | 0.407 | 1.96 | RF-LF |
| Mike Cameron | 105 | 9 | 9 | 0.149 | 0.210 | -0.39 | CF |
| Darnell McDonald | 83 | 9 | 13 | 0.160 | 0.241 | 0.51 | RF-LF-CF |
| Drew Sutton | 51 | 9 | 7 | 0.298 | 0.333 | 0.57 | X |
| Yamaico Navarro | 26 | 4 | 2 | 0.167 | 0.231 | 0.07 | X |
| Jose Iglesias | 4 | 0 | 0 | 0.000 | 0.000 | -0.09 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Josh Beckett | 126.0 | 2.07 | 19 | 0 | X | 5.21 |
| Jon Lester | 114.3 | 3.31 | 18 | 0 | X | 1.43 |
| Tim Wakefield | 92.7 | 5.15 | 13 | 9 | X | -2.82 |
| John Lackey | 91.7 | 6.28 | 16 | 0 | X | -5.22 |
| Clay Buchholz | 82.7 | 3.48 | 14 | 0 | X | 0.69 |
| Alfredo Aceves | 68.0 | 3.44 | 4 | 24 | X | 0.64 |
| Daniel Bard | 48.7 | 1.85 | 0 | 47 | X | 2.26 |
| Jonathan Papelbon | 41.7 | 3.67 | 0 | 42 | X | 0.17 |
| Matt Albers | 39.3 | 2.29 | 0 | 32 | X | 1.43 |
| Daisuke Matsuzaka | 37.3 | 5.30 | 7 | 1 | X | -1.27 |
| Dan Wheeler | 31.7 | 5.40 | 0 | 30 | X | -1.15 |
| Andrew Miller | 31.0 | 4.65 | 6 | 0 | X | -0.58 |
| Bobby Jenks | 15.7 | 6.32 | 0 | 18 | X | -0.91 |
| Scott Atchison | 15.3 | 4.70 | 0 | 9 | X | -0.31 |
| Kyle Weiland | 10.0 | 8.10 | 2 | 0 | X | -0.99 |
| Franklin Morales | 10.0 | 4.50 | 0 | 11 | X | -0.15 |
| Hideki Okajima | 8.3 | 4.32 | 0 | 7 | X | -0.09 |
| Rich Hill | 8.0 | 0.00 | 0 | 9 | X | 0.72 |
| Michael Bowden | 7.0 | 1.29 | 0 | 6 | X | 0.42 |
| Tommy Hottovy | 4.0 | 6.75 | 0 | 8 | X | -0.27 |
| Felix Doubront | 2.7 | 6.75 | 0 | 3 | X | -0.18 |
| Randy Williams | 2.0 | 13.50 | 0 | 2 | X | -0.45 |
| Dennys Reyes | 1.7 | 10.80 | 0 | 4 | X | -0.27 |
_