| Tm | Name | W | L | Start | End | |
|---|---|---|---|---|---|---|
| BOS | Jimmy Collins | 78 | 74 | Beg | End | |
| BOS | Fred Tenney | 51 | 103 | Beg | End | |
| CHA | Fielder Jones | 92 | 60 | Beg | End | |
| CHN | Frank Selee | 37 | 28 | Beg | 19050627 | |
| CHN | Frank Chance | 55 | 33 | 19050701 | End | |
| CIN | Joe Kelley | 79 | 74 | Beg | End | |
| CLE | Nap Lajoie | 37 | 21 | Beg | 19050701 | |
| CLE | Bill Bradley | 20 | 21 | 19050702 | 19050816 | |
| CLE | Nap Lajoie | 19 | 36 | 19050817 | End | |
| DET | Bill Armour | 79 | 74 | Beg | End | |
| LAN | Ned Hanlon | 48 | 104 | Beg | End | |
| NYA | Clark Griffith | 71 | 78 | Beg | End | |
| OAK | Connie Mack | 92 | 56 | Beg | End | |
| PHI | Hugh Duffy | 83 | 69 | Beg | End | |
| PIT | Fred Clarke | 96 | 57 | Beg | End | |
| SFN | John McGraw | 105 | 48 | Beg | End | |
| SLN | Jimmy McAleer | 54 | 99 | Beg | End | |
| SLN | Kid Nichols | 5 | 9 | Beg | 19050503 | |
| SLN | Jimmy Burke | 34 | 56 | 19050504 | 19050809 | |
| SLN | Stan Robison | 19 | 31 | 19050810 | End | |
| TEX | Jake Stahl | 64 | 87 | Beg | End |
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