| Tm | Name | W | L | Start | End | |
|---|---|---|---|---|---|---|
| BOS | Bob Coleman | 42 | 51 | Beg | 19450729 | |
| BOS | Joe Cronin | 71 | 83 | Beg | End | |
| BOS | Del Bissonette | 25 | 34 | 19450731 | End | |
| CHA | Jimmy Dykes | 71 | 78 | Beg | End | |
| CHN | Charlie Grimm | 98 | 56 | Beg | End | |
| CIN | Bill McKechnie | 61 | 93 | Beg | End | |
| CLE | Lou Boudreau | 73 | 72 | Beg | End | |
| DET | Steve O'Neill | 88 | 65 | Beg | End | |
| LAN | Leo Durocher | 87 | 67 | Beg | End | |
| NYA | Joe McCarthy | 81 | 71 | Beg | End | |
| OAK | Connie Mack | 52 | 98 | Beg | End | |
| PHI | Freddie Fitzsimmons | 18 | 51 | Beg | 19450629 | |
| PHI | Ben Chapman | 28 | 57 | 19450630 | End | |
| PIT | Frankie Frisch | 82 | 72 | Beg | End | |
| SFN | Mel Ott | 78 | 74 | Beg | End | |
| SLN | Luke Sewell | 81 | 70 | Beg | End | |
| SLN | Billy Southworth | 95 | 59 | Beg | End | |
| TEX | Ossie Bluege | 87 | 67 | Beg | End |
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