| Tm | Name | W | L | Start | End | |
|---|---|---|---|---|---|---|
| BOS | Joe Cronin | 104 | 50 | Beg | End | |
| BOS | Billy Southworth | 81 | 72 | Beg | End | |
| CHA | Jimmy Dykes | 10 | 20 | Beg | 19460524 | |
| CHA | Ted Lyons | 64 | 60 | 19460526 | End | |
| CHN | Charlie Grimm | 82 | 71 | Beg | End | |
| CIN | Bill McKechnie | 64 | 86 | Beg | 19460925 | |
| CIN | Hank Gowdy | 3 | 1 | 19460927 | End | |
| CLE | Lou Boudreau | 68 | 86 | Beg | End | |
| DET | Steve O'Neill | 92 | 62 | Beg | End | |
| LAN | Leo Durocher | 96 | 60 | Beg | End | |
| NYA | Joe McCarthy | 22 | 13 | Beg | 19460523 | |
| NYA | Bill Dickey | 57 | 48 | 19460525 | 19460912 | |
| NYA | Johnny Neun | 8 | 6 | 19460913 | End | |
| OAK | Connie Mack | 49 | 105 | Beg | End | |
| PHI | Ben Chapman | 69 | 85 | Beg | End | |
| PIT | Frankie Frisch | 62 | 89 | Beg | 19460927 | |
| PIT | Spud Davis | 1 | 2 | 19460928 | End | |
| SFN | Mel Ott | 61 | 93 | Beg | End | |
| SLN | Eddie Dyer | 98 | 58 | Beg | End | |
| SLN | Luke Sewell | 53 | 71 | Beg | 19460828 | |
| SLN | Zack Taylor | 13 | 17 | 19460831 | End | |
| TEX | Ossie Bluege | 76 | 78 | Beg | End |
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