| Tm | Name | W | L | Start | End | |
|---|---|---|---|---|---|---|
| BAL | Paul Richards | 78 | 57 | Beg | 19610830 | |
| BAL | Lum Harris | 17 | 10 | 19610901 | End | |
| BOS | Pinky Higgins | 76 | 86 | Beg | End | |
| CHA | Al Lopez | 86 | 76 | Beg | End | |
| CHN | Vedie Himsl | 5 | 6 | Beg | 19610423 | |
| CHN | Harry Craft | 4 | 8 | 19610426 | 19610510 | |
| CHN | Vedie Himsl | 5 | 12 | 19610512 | 19610530 | |
| CHN | El Tappe | 2 | 0 | 19610531 | 19610601 | |
| CHN | Harry Craft | 3 | 1 | 19610602 | 19610604 | |
| CHN | Vedie Himsl | 0 | 3 | 19610605 | 19610607 | |
| CHN | El Tappe | 35 | 43 | 19610609 | 19610831 | |
| CHN | Lou Klein | 5 | 6 | 19610901 | 19610910 | |
| CHN | El Tappe | 5 | 11 | 19610912 | End | |
| CIN | Fred Hutchinson | 93 | 61 | Beg | End | |
| CLE | Jimmy Dykes | 77 | 83 | Beg | 19610930 | |
| CLE | Mel Harder | 1 | 0 | 19611001 | End | |
| DET | Bob Scheffing | 101 | 61 | Beg | End | |
| KCA | Joe Gordon | 26 | 33 | Beg | 19610618 | |
| KCA | Hank Bauer | 35 | 67 | 19610619 | End | |
| LAN | Walter Alston | 89 | 65 | Beg | End | |
| LA_A | Bill Rigney | 70 | 91 | Beg | End | |
| MIL | Chuck Dressen | 71 | 58 | Beg | 19610902 | |
| MIL | Birdie Tebbetts | 12 | 13 | 19610903 | End | |
| MIN | Cookie Lavagetto | 19 | 30 | Beg | 19610605 | |
| MIN | Sam Mele | 2 | 5 | 19610606 | 19610612 | |
| MIN | Cookie Lavagetto | 4 | 6 | 19610613 | 19610622 | |
| MIN | Sam Mele | 45 | 49 | 19610623 | End | |
| NYA | Ralph Houk | 65 | 36 | Beg | 19610730 | |
| NYA | Frankie Crosetti | 6 | 1 | 19610802 | 19610806 | |
| NYA | Ralph Houk | 38 | 16 | 19610807 | End | |
| PHI | Gene Mauch | 47 | 107 | Beg | End | |
| PIT | Danny Murtaugh | 75 | 79 | Beg | End | |
| SFN | Al Dark | 85 | 69 | Beg | End | |
| SLN | Solly Hemus | 33 | 41 | Beg | 19610705 | |
| SLN | Johnny Keane | 47 | 33 | 19610706 | End | |
| TEX | Mickey Vernon | 61 | 100 | Beg | End |
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