| Tm | Name | W | L | Start | End | |
|---|---|---|---|---|---|---|
| ANA | Mike Scioscia | 95 | 67 | Beg | End | |
| ARI | Bob Melvin | 77 | 85 | Beg | End | |
| ATL | Bobby Cox | 90 | 72 | Beg | End | |
| BAL | Lee Mazzilli | 51 | 56 | Beg | 20050803 | |
| BAL | Sam Perlozzo | 23 | 32 | 20050804 | End | |
| BOS | Terry Francona | 0 | 2 | Beg | 20050405 | |
| BOS | Brad Mills | 2 | 2 | 20050406 | 20050410 | |
| BOS | Terry Francona | 9 | 6 | 20050411 | 20050426 | |
| BOS | Brad Mills | 2 | 1 | 20050429 | 20050501 | |
| BOS | Terry Francona | 20 | 18 | 20050502 | 20050612 | |
| BOS | Brad Mills | 1 | 0 | 20050613 | 20050613 | |
| BOS | Terry Francona | 61 | 38 | 20050614 | End | |
| CHA | Ozzie Guillen | 99 | 63 | Beg | End | |
| CHN | Dusty Baker | 79 | 83 | Beg | End | |
| CIN | Dave Miley | 27 | 43 | Beg | 20050620 | |
| CIN | Jerry Narron | 46 | 46 | 20050621 | End | |
| CLE | Eric Wedge | 21 | 25 | Beg | 20050526 | |
| CLE | Buddy Bell | 1 | 0 | 20050527 | 20050527 | |
| CLE | Eric Wedge | 35 | 27 | 20050528 | 20050804 | |
| CLE | Robby Thompson | 1 | 0 | 20050805 | 20050805 | |
| CLE | Eric Wedge | 35 | 17 | 20050806 | End | |
| COL | Clint Hurdle | 67 | 95 | Beg | End | |
| DET | Alan Trammell | 71 | 91 | Beg | End | |
| HOU | Phil Garner | 89 | 73 | Beg | End | |
| KCA | Tony Pena | 8 | 25 | Beg | 20050510 | |
| KCA | Bob Schaefer | 6 | 12 | 20050511 | 20050531 | |
| KCA | Buddy Bell | 24 | 41 | 20050601 | 20050814 | |
| KCA | Bob Schaefer | 0 | 2 | 20050815 | 20050816 | |
| KCA | Buddy Bell | 18 | 26 | 20050817 | End | |
| LAN | Jim Tracy | 71 | 91 | Beg | End | |
| MIA | Jack McKeon | 83 | 79 | Beg | End | |
| MIL | Ned Yost | 81 | 81 | Beg | End | |
| MIN | Ron Gardenhire | 83 | 79 | Beg | End | |
| NYA | Joe Torre | 27 | 23 | Beg | 20050529 | |
| NYA | Joe Girardi | 0 | 1 | 20050531 | 20050531 | |
| NYA | Joe Torre | 68 | 43 | 20050601 | End | |
| NYN | Willie Randolph | 83 | 79 | Beg | End | |
| OAK | Ken Macha | 88 | 74 | Beg | End | |
| PHI | Charlie Manuel | 88 | 74 | Beg | End | |
| PIT | Lloyd McClendon | 55 | 78 | Beg | 20050831 | |
| PIT | Pete Mackanin | 0 | 1 | 20050902 | 20050902 | |
| PIT | Lloyd McClendon | 0 | 2 | 20050903 | 20050904 | |
| PIT | Pete Mackanin | 12 | 14 | 20050906 | End | |
| SDN | Bruce Bochy | 82 | 80 | Beg | End | |
| SEA | Mike Hargrove | 69 | 93 | Beg | End | |
| SFN | Felipe Alou | 75 | 87 | Beg | End | |
| SLN | Tony LaRussa | 100 | 62 | Beg | End | |
| TBA | Lou Piniella | 67 | 95 | Beg | End | |
| TEX | Buck Showalter | 79 | 83 | Beg | End | |
| TOR | John Gibbons | 80 | 82 | Beg | End | |
| WAS | Frank Robinson | 81 | 81 | Beg | End |
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